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Gut Enterobacteriaceae predicts stroke outcome

ABSTRACT: Clinical experiment: gut Enterobacteriaceae was an independent predictor for outcome of ischemic stroke patients

PROVIDER: PRJEB28221 | ENA |

REPOSITORIES: ENA

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Gut Enterobacteriaceae predicts stroke outcome training

Project description:Clinical experiment: gut Enterobacteriaceae was an independent predictor for outcome of ischemic stroke patients.

| PRJEB28220 | ENA

Stroke Dysbiosis index (SDI) predicts stroke severity and early outcome.(Training)

Project description:Clinical experiment: gut microbiota pattern in stroke patients (stroke dysbiosis index, SDI) was an independent predictor for early outcome of ischemic stroke patients

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Stroke Dysbiosis index (SDI) predicts stroke severity and early outcome.(Validation)

Project description:Clinical experiment: gut microbiota pattern in stroke patients (stroke dysbiosis index, SDI) was an independent predictor for early outcome of ischemic stroke patients

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The role of a mammalian network in regulating ischemic stroke outcome II

Project description:To detect mRNAs in ischemic stroke animals we dissected contralateral (CL) and peri-ischemic (PI) cortex of transient middle cerebral artery occlusion (tMCAo) mice wild-type and ciRS-7 KO We performed differentially expression analysis of RNA-seq of wild-type and ciRS-7 KO tMCAo ischemic mice

2023-01-31 | GSE213177 | GEO

Gene expression analysis of peripheral whole blood RNA following ischemic stroke

Project description:The purpose of this project was to elucidate gene expression in the peripheral whole blood of acute ischemic stroke patients to identify a panel of genes for the diagnosis of acute ischemic stroke. Peripheral blood samples were collected in Paxgene Blood RNA tubes from stroke patients who were >18 years of age with MRI diagnosed ischemic stroke and controls who were non-stroke neurologically healthy. The results suggest a panel of genes can be used to diagnose ischemic stroke, and provide information about the biological pathways involved in the response to acute ischemic stroke in humans. Total RNA extracted from whole blood in n=39 ischemic stroke patients compared to n=24 healthy control subjects.

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Altered granulopoiesis aggravates stroke in the elderly [bulk RNA-seq]

Project description:Ischemic stroke is one of the leading causes of disability and mortality worldwide, recognizing aging as a prominent risk factor and determinant of dismal outcome. Aging is known to lead to overall frailty due to multifactorial changes, but pathogenic mechanisms underlying poor outcome remain unclear. Here we show that deterioration in elderly stroke is preceded by neutrophil accumulation and clogging in the ischemic brain microcirculation leading to a worse no-reflow phenomenon. With high-dimensional single-cell profiling over time of the brain's, blood's, and bone marrow's immune response, we could delineate after stroke four main neutrophil clusters in the blood whose quantitative and temporal dynamic of release is deranged in the bone marrow of the old. In the elderly, stroke triggers an early surge in the blood of the CD62Llo neutrophil subset characterized by a signature of bone marrow proximity, senescence, and oxidative stress. Functionally, transfer of this neutrophil subset displaying prominent thrombogenic features in young stroke mice leads to increased clogging of the ischemic brain microcirculation, worse no-reflow and outcome. Interrogating the blood leukocyte landscape of a large human stroke cohort with extensive single-cell proteome analyses, we confirmed that older stroke patients display a similar precocious accumulation of blood CD62Llo neutrophil subset, worse reperfusion and outcome. Our results demonstrate how age-related alterations in the process of neutrophil differentiation and release from the bone marrow have a relevant pathogenic role in the major cerebrovascular disorder affecting the world population, that unleash emergency granulopoiesis.

2023-05-16 | GSE174438 | GEO

The role of a mammalian network in regulating ischemic stroke outcome II

Project description:The role of a mammalian network in regulating ischemic stroke outcome II

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The role of a mammalian network in regulating ischemic stroke outcome III

Project description:The role of a mammalian network in regulating ischemic stroke outcome III

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The role of a mammalian network in regulating ischemic stroke outcome I

Project description:The role of a mammalian network in regulating ischemic stroke outcome I

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The transcriptional landscape of pericytes in acute ischemic stroke

Project description:The current treatment options for ischemic stroke aim to achieve reperfusion but are time critical. Novel therapeutic approaches that can be given beyond the limited time window of 3 - 4.5 hours are still an unmet need to be addressed to improve stroke outcome. The lack of oxygen and glucose in the area of ischemic injury initiates a pathological cascade leading to blood-brain barrier (BBB) breakdown, inflammation and neuronal cell death, a process that may be intercepted to limit stroke progression. Pericytes located at the blood/brain interface are one of the first responders to hypoxia in stroke and therefore a potential target cell for early stroke interventions. Using single-cell RNA sequencing in a mouse model of permanent middle cerebral artery occlusion, we investigated the temporal differences in transcriptomic signatures in pericytes at 1, 12, and 24 hours after stroke compared to the contralateral hemisphere. Our results reveal a stroke-specific subcluster of pericytes that is present at 12 and 24 hours and characterized by the upregulation of genes mainly related to cytokine signalling and immune response. This study identifies temporal transcriptional changes in the acute phase of ischemic stroke that reflect the early response of pericytes to the ischemic insult and its secondary consequences and may constitute potential future therapeutic targets.

2023-06-29 | GSE234052 | GEO

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