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Next generation sequencing based microsatellite instability test using single molecule molecular inversion probes

ABSTRACT: A molecular inversion probe and sequencing-based microsatellite instability assay for high throughput cancer diagnostics and Lynch syndrome screening

PROVIDER: PRJEB28394 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR2760860_1.fastq.gz	Fastqsanger.gz
	ERR2760860_2.fastq.gz	Fastqsanger.gz
	ERR2760870_1.fastq.gz	Fastqsanger.gz
	ERR2760870_2.fastq.gz	Fastqsanger.gz
	ERR2760880_1.fastq.gz	Fastqsanger.gz

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Colorectal cancers with microsatellite instability display unique miRNA profiles

Project description:Analysis of microRNA expression of tumoral and non-tumoral colonic tissues. The aim of this study was to analyze the global miRNA signatures in various groups of well-characterized CRCs based on the presence of microsatellite instability (MSI). Total RNA from formalin-fixed paraffin-embedded tissue blocks from 4 different groups (normal colonic mucosa, Lynch syndrome tumors, sporadic MSI tumors and MSS tumors) was isolated using the RecoverAll Total Nucleic Acid Isolation Kit (Ambion) according to manufacturer instructions. MiRNA expression profiles were analyzed using miRNA microarray platform.

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