Project description:we report the antitumor activity of an indole alkaloid, 3alpha-acetonyltabersonine, which was isolated from Melodinus suaveolens. 3alpha-acetonyltabersonine was found to be cytotoxic to glioblastoma cell line and stem cells at low concentrations.
Project description:Primary objectives: The primary objective is to investigate circulating tumor DNA (ctDNA) via deep sequencing for mutation detection and by whole genome sequencing for copy number analyses before start (baseline) with regorafenib and at defined time points during administration of regorafenib for treatment efficacy in colorectal cancer patients in terms of overall survival (OS).
Primary endpoints: circulating tumor DNA (ctDNA) via deep sequencing for mutation detection and by whole genome sequencing for copy number analyses before start (baseline) with regorafenib and at defined time points during administration of regorafenib for treatment efficacy in colorectal cancer patients in terms of overall survival (OS).