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Alterations of the gut microbiome and metabolism with progression of coronary artery disease

ABSTRACT: Coronary artery disease is one of the most prevalent cardiovascular diseases worldwide. The gut microbes-derived metabolites have been suggested to use as markers for major adverse cardiac event, yet the contributions of gut microbes and bacterial metabolites towards atherosclerosis remain largely uncharacterized. We indicated a relationship between the gut microbiome and metabolomics and provided preliminary evidence that gut dysbiosis interacts with metabolic pathways to affect atherosclerosis severity. Our findings point towards a new strategy aimed at reducing cardiovascular risks through restoring the homeostasis of gut microbiota.

PROVIDER: PRJEB29076 | ENA |

REPOSITORIES: ENA

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