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RNA-seq of neuronal SOX2-ablated murine suprachiasmatic nuclei against wild-type littermate controls

ABSTRACT: RNA-seq of neuronal SOX2-ablated murine suprachiasmatic nuclei against wild-type littermate controls

PROVIDER: PRJEB30100 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR2983480_1.fastq.gz	Fastqsanger.gz
	ERR2983480_2.fastq.gz	Fastqsanger.gz
	ERR2983490_1.fastq.gz	Fastqsanger.gz
	ERR2983490_2.fastq.gz	Fastqsanger.gz
	ERR2983500_1.fastq.gz	Fastqsanger.gz

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RNA-seq of neuronal SOX2-ablated murine suprachiasmatic nuclei against wild-type littermate controls

Project description:Mice lacking the stem/progenitor cell transcription factor, Sex determining region Y-box 2 (SOX2), in neurons of the suprachiasmatic nuclei display imprecise, poorly consolidated behavioral rhythms that do not entrain efficiently to environmental light cycles. RNA sequencing revealed that Sox2 deficiency alters the circadian transcriptome of the SCN, reducing the expression of many core clock genes and neuropeptide-receptor systems.

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