Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Effect of Bcl10 deletion in regulatory T cells

ABSTRACT: Effect of Bcl10 deletion in regulatory T cells

PROVIDER: PRJEB32185 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	ERR3293570_1.fastq.gz	Fastqsanger.gz
	ERR3293570_2.fastq.gz	Fastqsanger.gz
	ERR3293580_1.fastq.gz	Fastqsanger.gz
	ERR3293580_2.fastq.gz	Fastqsanger.gz
	ERR3293571_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 48

Similar Datasets

Effect of Sin3a deletion on gene expression within FoxP3+ T-regulatory cells

Project description:Effect of Sin3a deletion on gene expression within FoxP3+ T-regulatory cells

| PRJNA1099388 | ENA

Effect of Mll3 deletion in MCF7 cells

Project description:Effect of Mll3 deletion in MCF7 cells

| PRJNA719656 | ENA

Effect of Ikaros deletion on gene expression in CD4 T cells

Project description:Effect of Ikaros deletion on gene expression in CD4 T cells

| PRJNA488016 | ENA

Effect of hematopoietic Tet2 deletion on steatohepatitis

Project description:Effect of hematopoietic Tet2 deletion on steatohepatitis

| PRJNA927295 | ENA

Effect of Xq28 deletion on hypergonadotropic hypogonadism

Project description:Effect of Xq28 deletion on hypergonadotropic hypogonadism

| PRJNA662637 | ENA

Effect of Xq28 deletion on hypergonadotropic hypogonadism

Project description:Effect of Xq28 deletion on hypergonadotropic hypogonadism

| PRJNA662636 | ENA

DEK1 deletion effect on Physcomitrella patens transcriptome

Project description:DEK1 deletion effect on Physcomitrella patens transcriptome

| PRJEB6339 | ENA

Effect of Sin3a deletion on gene expression within FoxP3+ T-regulatory cells

Project description:Foxp3 (forkhead box protein 3) functions as the master transcriptional regulator of Treg phenotype. Histone deacetylases 1 and 2 (HDAC1/2) contribute to the regulation of FoxP3 expression via interactions with a myriad of co-regulatory factors. While the nuclear scaffolding protein, Sin3a, has been well established as a co-factor of HDAC1/2, its role within FoxP3+ Tregs has not been. We analyzed the effects of conditional deletion of Sin3a in Foxp3+ Treg cells using three orthogonal approaches. Deletion of Sin3a from FoxP3+ Tregs resulted in the rapid onset of severe and fatal autoimmunity mirroring the phenotype of Scurfy mice. Numbers of Tregs were greatly reduced, residual Tregs had virtually complete loss of suppressive function, and inducible Treg production was blocked. Mice also showed activation of effector T cells, autoantibody production and widespread tissue injury. Mechanistically, Sin3a deletion resulted in decreased transcription of Foxp3 and other Treg signature genes. The reduction of Foxp3 expression was accompanied by the reduction of TET1 and 3 expression and a complete lack of CpG demethylation of the Foxp3 enhancer region CNS2. In addition, Foxp3 protein stability was impaired and fate mapping studies showed conversion of Tregs to ex-Tregs and increased rates of programmed cell death. Thus, Sin3a plays a critical role in the maintenance of Treg identity and function and is essential for the expression and stability of Foxp3.

2024-06-07 | GSE263830 | GEO

Effect of Bcl11b deletion in resting and activated mouse CD4+ T cells.

Project description:Effect of Bcl11b deletion in resting and activated mouse CD4+ T cells.

| PRJNA925835 | ENA

Effect of ∆Np63 deletion on plasticity of post-injury lung basal cells

Project description:Effect of ∆Np63 deletion on plasticity of post-injury lung basal cells

| PRJNA892466 | ENA