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RNA-seq of hypothalamus from Zrsr1 WT and Zrsr1 mutant mice.

ABSTRACT: RNA-seq of hypothalamus from Zrsr1 WT and Zrsr1 mutant mice.

PROVIDER: PRJEB32844 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR3348230_1.fastq.gz	Fastqsanger.gz
	ERR3348230_2.fastq.gz	Fastqsanger.gz
	ERR3348231_1.fastq.gz	Fastqsanger.gz
	ERR3348231_2.fastq.gz	Fastqsanger.gz
	ERR3348226_1.fastq.gz	Fastqsanger.gz

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RNA-seq of hypothalamus from Zrsr1 WT and Zrsr1 mutant mice.

Project description:Splicing factor ZRSR1 is known to have a role in spermatogenesis and fertility, leading its mutation to several reproductive defects in male. To investigate if Zrsr1 gene is involved in male reproductive control by the hypothalamus, we performed RNA-seq to determine the differences in gene expression, usage of isoforms and alternative splicing between the hypothalamus of WT mice and from Zrsr1mu mice.

2019-07-19 | E-MTAB-8012 | biostudies-arrayexpress

E-MTAB-8012

Project description:RNA-seq of hypothalamus from Zrsr1 WT and Zrsr1 mutant mice.

2020-07-15 | E-MTAB-8012 | ExpressionAtlas

Impaired spermatogenesis, muscle and erythrocyte function in U12 intron splicing-defective Zrsr1 mutant mice

Project description:We analysed the gene expression in testis of Zrsr1 mutant mice. We generated mutant mice containing truncating mutations within the RNA-recognition motif (RRM) in Zrsr1 locus. The RNAs of testes from 4 WT and 5 Zrsr1 mutant mice at day 15, immediately after the peak of expression of Zrsr1 in developing testis, were prepared and sequenced in order to identify and characterize the RNAs regulated by Zrsr1 in developing testis.

2018-04-03 | E-MTAB-4872 | biostudies-arrayexpress

RNA-seq of Zrsr1-2WT and Zrsr1-2 mutant embryos

Project description:Zrsr1 and Zrsr2 are two paralogous genes, whose products play a key role in minor splicing. To investigate the effects of minor splicing during early embryo development, embryos from Zrsr2 mutant females and Zrsr1 mutant males were produced, showing an impaired development during zygotic gene activation at the 2-cell stage. RNA-seq of these embryos was performed to check the complementation of these two genes during this stage.

2020-06-15 | E-MTAB-9102 | biostudies-arrayexpress

RNA-seq of Zrsr1-2WT and Zrsr1-2 mutant embryos

Project description:RNA-seq of Zrsr1-2WT and Zrsr1-2 mutant embryos

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ZRSR1 cooperates with ZRSR2 in regulating splicing of U12-type introns in murine hematopoietic cells

Project description:Recurrent loss-of-function mutations of spliceosome gene, ZRSR2, occur in myelodysplastic syndromes (MDS). Mutation/loss of ZRSR2 in human myeloid cells primarily causes impaired splicing of the U12-type introns. To investigate further the role of this splice factor in splicing and hematopoietic development, we generated mice lacking ZRSR2. Unexpectedly, Zrsr2-deficient mice developed normal hematopoiesis with no abnormalities in myeloid differentiation evident in either young or ≥1-year old knockout mice. Repopulation ability of Zrsr2-deficient hematopoietic stem cells was also unaffected in reconstitution assays. Myeloid progenitors lacking ZRSR2 exhibited mis-splicing of U12-type introns, however, this phenotype was moderate compared to the ZRSR2-deficient human cells. Our investigations revealed that a closely related homolog, Zrsr1, expressed in the murine hematopoietic cells, but not human, contributes to splicing of U12-type introns. Depletion of Zrsr1 in Zrsr2 KO myeloid cells exacerbated retention of the U12-type introns, thus highlighting a collective role of ZRSR1 and ZRSR2 in murine U12-spliceosome. We also demonstrate that aberrant retention of U12-type introns of MAPK9 and MAPK14 leads to their reduced protein expression. Overall, our findings highlight that both ZRSR1 and ZRSR2 are functional components of the murine U12-spliceosome, and depletion of both proteins is required to model accurately ZRSR2-mutant MDS in mice.

2022-03-09 | GSE152432 | GEO

Impaired spermatogenesis, muscle and erythrocyte function in U12 intron splicing-defective Zrsr1 mutant mice

Project description:Impaired spermatogenesis, muscle and erythrocyte function in U12 intron splicing-defective Zrsr1 mutant mice

| PRJEB14620 | ENA

ZRSR1 cooperates with ZRSR2 in regulating splicing of U12-type introns in murine hematopoietic cells II

2023-05-29 | GSE151471 | GEO

ZRSR1 cooperates with ZRSR2 in regulating splicing of U12-type introns in murine hematopoietic cells I

2022-03-09 | GSE151470 | GEO

Gene Expression Profile in the Hypothalamus of Male Bgn_KO and WT Mice at 13 Weeks Old

Project description:To investigate the effects of gene Bgn on affecting brain dysfunction and metabolic disorders by profiling the transcripome in the hypothalamus of male Bgn_KO and wild-type (WT, litter mate) mice at 13 weeks old.

2018-12-26 | GSE59742 | GEO

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