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ABSTRACT: EMG produced TPA metagenomics assembly of the PRJEB9818 data set (The gut DNA viromes of Malawian twins discordant for severe acute undernutrition).

PROVIDER: PRJEB33329 | ENA |

REPOSITORIES: ENA

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Dataset's files

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			Action	DRS
	ERR975051.fasta.gz	Fasta.gz
	ERR975051.bam	Bam
	ERR975051.bam.bai	Bam
	ERR975054.fasta.gz	Fasta.gz
	ERR975054.bam	Bam

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1 - 5 of 33

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Malawi infant viromes

Project description:The gut DNA viromes of Malawian twins discordant for severe acute undernutrition

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Methylomic Analysis reveals Epigenetic Pattern of SH2B1 in Chinese Monozygotic Twins Discordant for Autism Spectrum Disorder [Bisulfite-seq]

Project description:Autism spectrum disorder(ASD) is a complex neurodevelopmental disorder. Aberrant DNA methylation has been observed in ASD but the mechanisms remain largely unknown. Here, we employed discordant monozygotic twins to investigate the contribution of DNA methylation to ASD etiology. Genome-wide DNA methylation analysis was performed using samples obtained from five pairs of ASD-discordant monozygotic twins, which revealed a total of 2397 differentially methylated genes. Further, such gene list was annotated with Kyoto Encyclopedia of Genes and Genomes and demonstrated predominant activation of neurotrophin signaling pathway in ASD-discordant monozygotic twins. The methylation of SH2B1 gene was further confirmed in the ASD-discordant, ASD-concordant monozygotic twins, and a set of 30 pairs of sporadic case-control by bisulfite-pyrosequencing. The results showed that there was a greater DNA methylation difference in ASD-discordant monozygotic twins than ASD-concordant monozygotic twins. Further, verification of the Chr.16:28856743 of SH2B1 showed significant differences in DNA methylation between case and control. These results suggest abnormal methylation of SH2B1 is associated with ASD etiology. Our data suggest that it might be worthwhile to further explore the functions of SH2B1 and related genes of neurotrophin signaling pathway in ASD.

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PLASMA PROTEOMIC ANALYSIS OF RARE BMI-DISCORDANT MONOZYGOTIC TWIN PAIRS

Project description:The aim of the current study is to establish the effect of excess body wiehgt and liver fat on plasma proteomic profile without interference from genetic variation. Label-free proteomics (HDMSE) was performed on plasma samples of young healthy monozygotic twins who were discordant for BMI. the twins were further subdivided into groups of liver fat discordant and liver fat concordant to see the efefct fo liver fat on plasma proteomic signature.

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Project description:EMG produced TPA metagenomics assembly of PRJNA986291 data set (CForBio.metagenome).

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Project description:EMG produced TPA metagenomics assembly of PRJNA639280 data set (v).

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Project description:EMG produced TPA metagenomics assembly of PRJEB30246 data set (Metagenomic_analysis_nasopharyngeal_colonisation).

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Gene expression analysis in MZ twins discordant for IAR [in vitro]

Project description:Gene expression analysis in CD4+ T cells extracted from allergen-challenged PBMCs, isolated from discordant MZ twins with IAR MZ twins discordant for intermittent allergic rhinitis (IAR)

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Gene expression analysis in MZ twins discordant for IAR [in vivo]

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