Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

RNAseq of isolated pancreatic islets from SUSD4 KO and control mice

ABSTRACT: RNAseq of isolated pancreatic islets from SUSD4 KO and control mice

PROVIDER: PRJEB33494 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	ERR3433100.fastq.gz	Fastqsanger.gz
	ERR3433101.fastq.gz	Fastqsanger.gz
	ERR3433102.fastq.gz	Fastqsanger.gz
	ERR3433103.fastq.gz	Fastqsanger.gz
	ERR3433104.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 12

Similar Datasets

Ring1b profiling in pancreatic islets

Project description:To gain insights into how pancreatic cells are programmed in vivo, we profiled RNA expression in pancreatic islets of pancreatic Ring1b conditional KO mice (conditional using a pancreas specfic Cre; Pdx1-Cre) and their littermate controls

2013-02-10 | E-MTAB-1404 | biostudies-arrayexpress

Global transcriptomic analysis of human pancreatic islets [RNAseq]

Project description:Global transcriptomic analysis of human pancreatic islets [RNAseq]

| PRJNA422401 | ENA

Cdh13 null mice isolated islets RNAseq

Project description:The pancreas islets RNA expressions were compared between WT (exon2 floxed) mice and Cdh13 KO (exon2 deleted) mice. The islets were isolated from the mice at 8wks old, 14wks old under normal chow diet, and 14wks old under HFD conditions.

2022-12-09 | GSE186944 | GEO

RNA-seq of mouse islets from Ins1-cre driven Cnot3 KO and control islets

Project description:The CCR4-NOT dedadenylase complex is essential for mRNA decay and various biological events.To understand roles of the complex in pancreatic beta cells, we compared global gene expression in Ins1-cre driven Cnot3 KO and control islets. Cnot3 is an important subunit of the complex and its knockout affects the complex activity.

2020-08-29 | E-MTAB-8729 | biostudies-arrayexpress

RNA seq of pancreatic islets isolated from free fatty acid receptor 3 knockout (Ffar3 KO) and wildtype (Ffar3 WT) male mice

Project description:The short chain fatty acid (SCFA) receptor (free fatty acid receptor-3; FFAR3) is expressed in pancreatic beta cells; however, its role in insulin secretion is not clearly defined. Here, we examined the role of FFAR3 in insulin secretion. Using islets from global knockout FFAR3 (Ffar3-/-) mice, we explored the role of FFAR3 and ligand-induced FFAR3 signaling on glucose stimulated insulin secretion. RNA sequencing was also performed to gain greater insight into the impact of FFAR3 deletion on the islet transcriptome. First exploring insulin secretion, it was determined that Ffar3-/- islets secrete more insulin in a glucose-dependent manner as compared to wildtype (WT) islets. Next, exploring its primary endogenous ligand, propionate, and a specific agonist for FFAR3, signaling by FFAR3 inhibited glucose-dependent insulin secretion, which occurred through a GÎ±i/o pathway. To help understand these results, transcriptome analyses by RNA-sequencing of Ffar3-/- and WT islets observed multiple genes with well known roles in islet biology to be altered by genetic knockout of FFAR3. Our data shows that FFAR3 signaling mediates glucose stimulated insulin secretion through GÎ±i/o sensitive pathway. Future studies are needed to more rigorously define the role of FFAR3 by in vivo approaches. Analysis of total RNA from 3 biological replicates of pancreatic islets isolated from free fatty acid receptor 3 knockout (Ffar3 KO) and wildtype (Ffar3 WT) male mice

2016-07-03 | E-GEOD-67991 | biostudies-arrayexpress

RNAseq analysis of islets from murine Abca12 KO pancreas

Project description:RNAseq analysis of islets from murine Abca12 KO pancreas

| PRJNA589540 | ENA

Cdh13 null mice isolated islets RNAseq

Project description:Cdh13 null mice isolated islets RNAseq

| PRJNA776857 | ENA

RNA-Seq in pancreatic islets isolated from Arid1aFl/Fl control and Arid1aFl/Fl; UBC-CreERT2 mice (Arid1a KO) with/without pancreatectomy.

Project description:To determine how ARID1A loss might regulate gene expression, we performed RNA-sequencing (RNA-seq) on islets isolated from control and Arid1a knockout (KO) mice at baseline and 6 days after 50% pancreatectomy (PPx).

2022-03-22 | GSE199187 | GEO

RNA-Seq in pancreatic islets isolated from Arid1aFl/Fl control and Arid1aFl/Fl; UBC-CreERT2 mice (Arid1a KO) with/without pancreatectomy

2022-04-21 | GSE201002 | GEO

Single cell RNAseq profiling of Human Pancreatic Islets across sex

Project description:Single cell RNAseq profiling of Human Pancreatic Islets across sex

| PRJNA1106513 | ENA