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CXCR3+ T cells in Multiple Sclerosis Correlate with Reduced Diversity of the Gut Microbiome

ABSTRACT: - Patients with MS exhibited decreased alpha diversity in the composition of their gut bacteria compared to healthy controls - Circulating lymphocytes from MS patients were enriched for Th1 (CXCR3+) and Th1-17 (CXCR3+ CCR6+) memory CD4+ cells and for CXCR5+ memory CD4+ cells - A higher proportion of CXCR3+ T-cells from MS patients co-expressed the gut homing receptor α4β7 compared to healthy controls Reduced alpha diversity correlated significantly with expression of CXCR3+ on CD8+ T-cells and CXCR5— memory T-cells.

PROVIDER: PRJEB34168 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR3507010_1.fastq.gz	Fastqsanger.gz
	ERR3507010_2.fastq.gz	Fastqsanger.gz
	ERR3507020_1.fastq.gz	Fastqsanger.gz
	ERR3507020_2.fastq.gz	Fastqsanger.gz
	ERR3507030_1.fastq.gz	Fastqsanger.gz

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