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ESBL-producing E.coli isolated from patients in Thailand

ABSTRACT: Extended-Spectrum Beta-lactamase -producing Escherichia coli strains isolated from diarrhea patients hospitalized in Thailand

PROVIDER: PRJEB34463 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR3528490_1.fastq.gz	Fastqsanger.gz
	ERR3528490_2.fastq.gz	Fastqsanger.gz
	ERR3528500_1.fastq.gz	Fastqsanger.gz
	ERR3528500_2.fastq.gz	Fastqsanger.gz
	ERR3528491_1.fastq.gz	Fastqsanger.gz

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Project description:The global surge in multi-drug resistant bacteria, including extended-spectrum β-lactamase (ESBL)-producing Escherichia coli has led to a growing need for new antibacterial compounds. Despite being promising, the potential of fish-derived antimicrobial peptides (AMPs) in combating ESBL-E. coli is largely unexplored. In this study, native peptides were extracted from the skin mucus of farmed African Catfish, Clarias gariepinus, using a combination of 10 % acetic acid solvent hydrolysis, 5 kDa ultrafiltration, and C18 hydrophobic interactions. Peptides were then sequenced using Orbitrap Fusion Lumos Tribrid Mass Spectrometry. The identified peptides were screened for potential antibacterial activity using Random Forest and AdaBoost machine learning algorithms. The most promising peptide was then chemically synthesized and evaluated in vitro for safety on Rabbit red blood cells and activity against ESBL-E. coli (ATCC 35218) utilizing the spot-on-lawn and broth dilution methods. Eight short peptides were identified with 13 - 22 amino acid residues and molecular weight range of 968.42 to 2434.11 Da. Peptide, FACAP-II was non-hemolytic to rabbit erythrocytes (p>0.05), with Zone of Inhibition (ZOI) of 22.7 mm and Minimum Inhibitory concentration (MIC) of 91.3 μg/mL. The peptide is thus a candidate antibacterial compound with enormous potential applications in the pharmaceutical industry. However, further studies are still required to establish the upscale production strategy and optimize its activity and safety in vivo.

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