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ABSTRACT: Colistin resistant Acinetobacter baumannii in Cape Town, South Africa

PROVIDER: PRJEB34692 | ENA |

REPOSITORIES: ENA

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			Action	DRS
		Other
	ERR3569450_1.fastq.gz	Fastqsanger.gz
	ERR3569450_2.fastq.gz	Fastqsanger.gz
	ERR3569451_1.fastq.gz	Fastqsanger.gz
	ERR3569451_2.fastq.gz	Fastqsanger.gz

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Colistin resistant A. baumannii: genomic and transcriptomic traits acquired under colistin therapy

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Project description:Colistin is a crucial last-line drug used for the treatment of life-threatening infections caused by multi-drug resistant strains of the Gram-negative bacteria, Acinetobacter baumannii. However, colistin resistant A. baumannii isolates can be isolated following failed colistin therapy. Resistance is most often mediated by the addition of phosphoethanolamine (pEtN) to lipid A by PmrC, following missense mutations in the pmrCAB operon encoding PmrC and the two-component signal transduction system PmrA/PmrB. We recovered an isogenic pair of A. baumannii isolates from a single patient before (6009-1) and after (6009-2) failed colistin treatment that displayed low/intermediate and high levels of colistin resistance, respectively. To understand how increased colistin-resistance arose, we genome sequenced each isolate which revealed that 6009-2 had an extra copy of the insertion sequence element ISAba125 within a gene encoding an H-NS-family transcriptional regulator. Consequently, transcriptomic analysis of the clinical isolates identified was performed and more than 150 genes as differentially expressed in the colistin-resistant, hns mutant, 6009-2. Importantly, the expression of eptA, encoding a second lipid A-specific pEtN transferase, but not pmrC, was significantly increased in the hns mutant. This is the first time an H-NS-family transcriptional regulator has been associated with a pEtN transferase and colistin resistance.

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