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Evolution of the MRSA clone ST228

ABSTRACT: Phylogeographical analysis reveals the historic origin, emergence, and evolutionary dynamics of methicillin-resistant Staphylococcus aureus ST228

PROVIDER: PRJEB34863 | ENA |

REPOSITORIES: ENA

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			Action	DRS
		Other
	ERR3623540_1.fastq.gz	Fastqsanger.gz
	ERR3623540_2.fastq.gz	Fastqsanger.gz
	ERR3623550_1.fastq.gz	Fastqsanger.gz
	ERR3623550_2.fastq.gz	Fastqsanger.gz

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The stealthy superbug: MRSA ST228

Project description:The role of asymptomatic enteric carriage in maintaining a long-term hospital outbreak of ST228 methicillin resistant Staphylococcus aureus

| PRJEB34139 | ENA

Genomic evolution of ST228 SCCmec-I MRSA 10 years after a major nosocomial outbreak.

Project description:In this study, we investigated the genomic changes in a major methicillin-resistant Staphylococcus aureus (MRSA) clone following a significant outbreak at a hospital. Whole-genome sequencing of MRSA isolates was utilized to explore the genomic evolution of post-outbreak MRSA strains. The epidemicity of the clone declined over time, coinciding with the introduction of multimodal infection control measures. A genome-wide association study (GWAS) identified multiple genes significantly associated with either high or low epidemic success, indicating alterations in mobilome, virulence, and defense mechanisms. Random Forest models pinpointed a gene related to fibrinogen binding as the most influential predictor of epidemicity. The decline of the MRSA clone may be attributed to various factors, including the implementation of new infection control measures, single nucleotide polymorphisms accumulation, and the genetic drift of a given clone. This research underscores the complex dynamics of MRSA clones, emphasizing the multifactorial nature of their evolution. The decline in epidemicity seems linked to alterations in the clone's genetic profile, with a probable shift towards decreased virulence and adaptation to long-term carriage. Understanding the genomic basis for the decline of epidemic clones is crucial to develop effective strategies for their surveillance and management, as well as to gain insights into the evolutionary dynamics of pathogen genomes.

| S-EPMC11250417 | biostudies-literature

Livestock-associated MRSA lack accessory virulence determinants of human-associated MRSA

Project description:Previous studies have documented the diversity of genetic background of methicillin-resistant S. aureus (MRSA) strains associated with healthcare (HA-MRSA), community (CA-MRSA) and livestock (LA-MRSA). The accessory and core-variable genome content of those strains remain largely unknown. To compare the composition of accessory and core-variable genome of Belgian MRSA strains according to host, population setting and genetic background, representative strains of HA- (n=21), CA- (n = 13) and ST398 LA-MRSA (n = 18) were characterized by a DNA-microarray (StaphVar Array) composed of oligonucleotide probes targeting ~400 resistance, adhesion and virulence associated genes.ST398 strains displayed very homogenous hybridization profiles (>94% gene content homology) irrespective of their host origin. This “ST398-specific” genomic profile was not distantly demarked from those of certain human-associated lineages but lacked several virulence- and colonization-associated genes harbored by strains of human origin, such as genes encoding proteases, haemolysins or adhesins. No enterotoxin gene was found among ST398 strains. In conclusion, our findings are consistent with a non-human origin of this ST398 lineage but suggest that it might have the potential to adapt further to the human host.

2010-11-15 | GSE20541 | GEO

Staphylococcus aureus ST228/16125

Project description:Staphylococcus aureus ST228/16125 genome sequencing project

| PRJEA71351 | ENA

Staphylococcus aureus ST228/10497

Project description:Staphylococcus aureus ST228/10497 genome sequencing project

| PRJEA71345 | ENA

Staphylococcus aureus ST228/16035

Project description:Staphylococcus aureus ST228/16035 genome sequencing project

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Staphylococcus aureus ST228/10388

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Staphylococcus aureus ST228/18412

Project description:Staphylococcus aureus ST228/18412 genome sequencing project

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Staphylococcus aureus ST228/18341

Project description:Staphylococcus aureus ST228/18341 genome sequencing project

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