Project description:The pheasant (Phasianus colchicus) is raised by commercial farms in most parts of China because of special fleshy flavour. In the study, complete mitochondrial genome of the Mongolia pheasant was sequenced by polymerase chain reaction (PCR) as well as the primer walking sequence method. The entire mitochondrial genome of Mongolia pheasant was 16,673?bp in length, gene composition and arrangement conformed to most bird, which contained the typical structure of 22 tRNAs, 2 rRNAs, 13 protein-coding genes and a non-coding region. The phylogenetic tree of 20 Phasianidaes showed that Mongolia pheasant had close relationship to ring-necked pheasant. Our complete mitochondrial genome sequence will be useful phylogenetics, and be available as basic data for the breeding and genetics.

| S-EPMC7800766 | biostudies-literature

Defining heritability, plasticity, and transition dynamics of cellular phenotypes in somatic evolution

Project description:Single-cell sequencing has revealed cell state heterogeneity across diverse healthy and malignant tissues. However, the extent these cell states are plastic or heritable remains largely unknown. To address this, we introduce PATH (Phylogenetic Analysis of Trait Heritability), a framework to quantify cell state heritability versus plasticity and infer cell state transition and proliferation dynamics from single-cell lineage tracing data. Here, we used PATH to measure phylogenetic correlations on single-cell phylogenies derived from gliomaspheres to reveal the somatic evolutionary relationships between Neural Progenitor-like (NPC), Oligodendrocyte Progenitor-like (OPC), Astrocyte-like (AC), and Mesenchymal-like (MES) cancer cell states.

2024-08-12 | GSE273357 | GEO

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