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RNA-seq of liver biopsies of eIF6 wild type and eIF6 heterozygous mice

ABSTRACT: RNA-seq of liver biopsies of eIF6 wild type and eIF6 heterozygous mice

PROVIDER: PRJEB38082 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR4082921_1.fastq.gz	Fastqsanger.gz
	ERR4082921_2.fastq.gz	Fastqsanger.gz
	ERR4082922_1.fastq.gz	Fastqsanger.gz
	ERR4082922_2.fastq.gz	Fastqsanger.gz
	ERR4082923_1.fastq.gz	Fastqsanger.gz

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RNA-seq of liver biopsies of eIF6 wild type and eIF6 heterozygous mice

Project description:A cohort of age-matched mice (eIF6+/+ and eIF6+/-) were fed with High-Fat Diet. All experimental mice were sacrificed after 16 weeks and the livers were recovered. RNA was isolated from liver biopsies of eIF6+/+ and eIF6+/- mice and RNAseq analysis was performed. The aim of the analysis is the investigation of the transcriptional changes driven by chronic depletion of eIF6 in the liver of mice upon High Fat Diet (HFD) feeding.

2021-06-18 | E-MTAB-9009 | biostudies-arrayexpress

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Skeletal muscle of Eif6 heterozygous mice

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Skeletal muscle of Eif6 heterozygous mice - soleus

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mRNA loading on polysomes in skeletal muscle of Eif6 heterozygous mice

Project description:Gastrocnemius muscle from Eif6 heterozygous mice and wild-type mice was used in a polysome profiling experiment. Total RNA was extracted from the whole muscle and from monosome/polysome fractions and profiled using Agilent gene expression arrays.

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Project description:Liver is primary involved in the response to insulin after feeding. Hepatocytes activates a tightly controlled genetic programme where specific sets of genes are modulates in response to insulin, for activation of the anabolic pathways. We used microarrays analysis to detail the global programme of gene expression in liver upon eIF6 haploinsufficiency and identified distinct classes of down-regulated genes and up-regulated genes during this process, that globally defines reprogramming of metabolism

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mRNA loading on polysomes in skeletal muscle of Eif6 heterozygous mice

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scRNA-seq of control and eIF6-overexpressing MLL-AF9 leukemia stem cells

Project description:Despite the advanced understanding of disease mechanisms, the current therapeutic regimens fail to cure most patients with acute myeloid leukemia (AML). In the present study, we address the role of protein synthesis control in leukemia function and leukemia propagation. Using a transgenic eIF6 mouse strain that permits inducible and graded regulation of ribosomal subunit joining, we have generated a murine model of MLL-AF9 acute myeloid leukemia where the expression of transgenic eIF6 is doxycycline-inducible. Using this model system, we have performed scRNA-seq expression analysis to study the impact of eIF6 overexpression on leukemia cell function. scRNA-seq was performed using the 10x Chromium Next GEM Single Cell 3ʹ platform. BM cells were harvested from leukemia-engrafted mice that were administered doxycycline for six days and viable GFP+ leukemia cells were sorted into PBS containing 0.05 % BSA following the manusfacturer’s protocol. 5 samples: 2 control and 3 eIF6 overexpression.

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