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MCL-1 ensures intestinal mucosal integrity and protects against WNT-driven carcinogenesis

ABSTRACT: RNA sequencing i-Apc i-Mcl-1 murine intestinal organoids vs i-Apc controls

PROVIDER: PRJEB38848 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR4436621_1.fastq.gz	Fastqsanger.gz
	ERR4436621_2.fastq.gz	Fastqsanger.gz
	ERR4436622_1.fastq.gz	Fastqsanger.gz
	ERR4436622_2.fastq.gz	Fastqsanger.gz
	ERR4436623_1.fastq.gz	Fastqsanger.gz

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Project description:Patients with conventional mantle cell lymphoma (MCL) show an aggressive clinical behavior. However, cases fulfilling the WHO criteria for MCL, but that remain asymptomatic without treatment, have been reported. In an attempt to understand this heterogeneity, we have compared 17 typical cases of MCL with a homogeneous group of 13 asymptomatic individuals with monoclonal expansion of t(11;14)(q13;q32) cyclin D1-positive B-cells in peripheral blood (MALD1). None of these cases have received treatment (minimum follow-up of 26 months; median, 71 months). Gene expression analysis has shown enrichment of signatures associated to neoplastic behavior and cell proliferation in MCL but not in MALD1. In contrast, MALD1 was highly enriched in gene sets related to immune activation and inflammatory responses. CD38 and CD200 genes were differentially expressed between MCL and MALD1. The combined assessment of both proteins by flow cytometry allowed classifying 85% of MALD1 cases. In summary, we have shown for the first time that MALD1, in contrast to MCL, is characterized by immune activation and driven by inflammatory cues. We have also shown that CD38 and CD200 flow cytometry assessment is useful to discern most cases of MALD1 from MCL in the clinical setting. MALD1 should be identified and segregated from the current MCL category to avoid overdiagnosis and unnecessary treatment.

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