Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

PA mutational signature in HCC

ABSTRACT: Mutational signature analysis reveals widespread contribution of pyrrolizidine alkaloid exposure to human liver cancer

PROVIDER: PRJEB39863 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	ERR9248320_1.fastq.gz	Fastqsanger.gz
	ERR9248320_2.fastq.gz	Fastqsanger.gz
	ERR9248330_1.fastq.gz	Fastqsanger.gz
	ERR9248330_2.fastq.gz	Fastqsanger.gz
	ERR9248340_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 90

Similar Datasets

Doxorubicin mutational signature

Project description:Doxorubicin mutational signature in HepG2 and MCF10A

| PRJEB30311 | ENA

Carboplatin mutational signature

Project description:Carboplatin mutational signature in HepG2 and MCF10A

| PRJEB30310 | ENA

Oxaliplatin mutational signature

Project description:Oxaliplatin mutational signature in HepG2 and MCF10A

| PRJEB30309 | ENA

Duocarmycin mutational signature in HepG2 cells

Project description:Duocarmycin mutational signature in HepG2 cells

| PRJEB33544 | ENA

Mutational signature of AA1 in MCF10A and HepG2

Project description:Mutational signature of AA1 in MCF10A and HepG2

| PRJEB36497 | ENA

Intragenomic variability and extended sequence patterns in the mutational signature of ultraviolet light

Project description:Mutational signatures can reveal properties of underlying mutational processes and are important when assessing signals of selection in cancer. Here we describe the sequence characteristics of mutations induced by ultraviolet (UV) light, a major mutagen in several human cancers, in terms of extended (longer than trinucleotide) patterns as well as variability of the signature across chromatin states. Promoter regions display a distinct UV signature with reduced TCG>TTG transitions, and genome-wide mapping of UVB-induced DNA photoproducts (pyrimidine dimers) showed that this may be explained by decreased damage formation at hypomethylated promoter CpG sites. Further, an extended signature model encompassing additional information from longer contextual patterns improves modeling of UV mutations, which may enhance discrimination between drivers and passenger events. Our study presents a refined picture of the UV signature and underscores that the characteristics of a single mutational process may vary across the genome.

2019-09-11 | GSE127966 | GEO

Mutational signature of aristolochic acid analogues in MCF10A and HepG2

Project description:Mutational signature of aristolochic acid analogues in MCF10A and HepG2

| PRJEB36499 | ENA

Colibactin DNA damage signature indicates mutational impact in colorectal cancer

Project description:Colibactin DNA damage signature indicates mutational impact in colorectal cancer

| PRJNA607699 | ENA

Colibactin DNA damage signature indicates mutational impact in colorectal cancer

Project description:Colibactin, a potent genotoxin of Escherichia coli, causes DNA double strand breaks (DSBs). We investigated if colibactin creates a particular DNA damage signature in infected human cells. Genomic contexts of colibactin-induced DSBs were enriched for a distinct AT-rich hexameric sequence motif. A survey of somatic mutations at the colibactin target sites of several thousand cancer genomes revealed significant enrichment of the motif in colorectal cancers. Moreover, the exact break point location corresponded with mutational hot spots in these cancers corresponding to a distinct trinucleotide signature. This work provides evidence for a role of colibactin in the etiology of human cancer.

2020-04-22 | GSE145594 | GEO

Mutational signature of AA1 in the presence of human S9 liver fraction

Project description:Mutational signature of AA1 in the presence of human S9 liver fraction

| PRJEB36498 | ENA