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MiR-124, miR-128, miR-137 miRNA synergism in neural derived tumors

ABSTRACT: miRNA synergism, combination of pro-neurogenic miRNAs as a more effective strategy to target neural derived tumors

PROVIDER: PRJEB40058 | ENA |

REPOSITORIES: ENA

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Dataset's files

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			Action	DRS
	ERR4551670.fastq.gz	Fastqsanger.gz
	ERR4551680.fastq.gz	Fastqsanger.gz
	ERR4551671.fastq.gz	Fastqsanger.gz
	ERR4551681.fastq.gz	Fastqsanger.gz
	ERR4551672.fastq.gz	Fastqsanger.gz

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MiR-124 synergism with ELAVL3 enhances target gene expression to promote neuronal maturity [Rat_Neurons_RNAseq]

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miR-124, -128 and -137 orchestrate neural differentiation by acting on overlapping gene sets containing a highly connected transcription factor network

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MicroRNAs miR-25, let-7 and miR-124 regulate the neurogenic potential of Müller glia in mice [RNA-Seq]

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MiR-124 synergism with ELAVL3 enhances target gene expression to promote neuronal maturity.

Project description:Neuron-enriched microRNAs (miRNAs), miR-9/9* and miR-124 (miR-9/9*-124), direct cell fate switching of human fibroblasts to neurons when ectopically expressed by repressing antineurogenic genes. How these miRNAs function after the repression of fibroblast genes for neuronal fate remains unclear. Here, we identified targets of miR-9/9*-124 as reprogramming cells activate the neuronal program and reveal the role of miR-124 that directly promotes the expression of its target genes associated with neuronal development and function. The mode of miR-124 as a positive regulator is determined by the binding of both AGO and a neuron-enriched RNA-binding protein, ELAVL3, to target transcripts. Although existing literature indicates that miRNA-ELAVL family protein interaction can result in either target gene up-regulation or down-regulation in a context-dependent manner, we specifically identified neuronal ELAVL3 as the driver for miR-124 target gene up-regulation in neurons. In primary human neurons, repressing miR-124 and ELAVL3 led to the down-regulation of genes involved in neuronal function and process outgrowth and cellular phenotypes of reduced inward currents and neurite outgrowth. Our results highlight the synergistic role between miR-124 and RNA-binding proteins to promote target gene regulation and neuronal function.

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MiR-124 synergism with ELAVL3 enhances target gene expression to promote neuronal maturity

Project description:MiR-124 synergism with ELAVL3 enhances target gene expression to promote neuronal maturity

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MiR-124 synergism with ELAVL3 enhances target gene expression to promote neuronal maturity [HNs_RNAseq]

Project description:MiR-124 synergism with ELAVL3 enhances target gene expression to promote neuronal maturity [HNs_RNAseq]

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