Project description:Streptococcus (S.) pneumoniae is the most frequently isolated causative pathogen community-acquired pneumonia, a leading cause of mortality worldwide. We investigated the role of the inflammasome sensor NLRP3 and the inflammasome adapter ASC during S. pneumoniae pneumonia. Detailed analysis of the early inflammatory response in the lung by whole genome transcriptional profiling, we identified several mediators that were differentially expressed between Nlrp3-/- and Asc-/ - mice.
Project description:Klebsiella pneumoniae is a gram-negative bacterium that can cause lung disease in humans. Meanwhile, the contamination situation of Klebsiella pneumoniae in aquaculture environment is critical. In this study, we determined for the first time the growth of Klebsiella pneumoniae isolated from common edible aquatic products in different carbon sources.
Project description:Klebsiella pneumoniae is a gram-negative bacterium that can cause lung disease in humans. Meanwhile, the contamination situation of Klebsiella pneumoniae in aquaculture environment is critical. In this study, we determined for the first time the growth of Klebsiella pneumoniae isolated from common edible aquatic products in different carbon sources.
Project description:To investigate the whole-genome gene expression difference between the wild-type and capsule deletion mutant in Klebsiella pneumoniae MGH 78578. The mutants analyzed in this study are further described in Huang T.W., Stapleton J.C., Chang H.Y., Tsai S.F., Palsson B.O., Charusanti P. Capsule removal via lambda-Red knockout system perturbs biofilm formation and fimbriae extression in Klesiella pneumoniae MGH 78578 (manuscript submission)