Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Pneumocystis carinii pneumonia Diagnosis via Metagenomic Next-Generation Sequencing

ABSTRACT: Pneumocystis carinii pneumonia Diagnosis via Metagenomic Next-Generation Sequencing

PROVIDER: PRJEB43652 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

DNA methylation analysis in Pneumocystis carinii using bisulfite sequencing

Project description:Pneumocystis carinii bisulfite_seq

2024-02-08 | GSE255176 | GEO

Microarray studies on effect of Pneumocystis carinii infection on global gene expression in alveolar macrophages

Project description:With a filter of false-discovery rate less than 0.1 and fold change greater than 1.5, 115 genes were found to be up- and 137 were down-regulated in alveolar macrophages during Pneumocystis carinii infection. Total RNA samples from 4 each of normal, dexamethasone-treated, and Pneumocystis carinii-infected Sprague-Dawley rats were analyzed by the Affymetrix GeneChip RG-U34A

2010-04-12 | E-GEOD-20149 | biostudies-arrayexpress

Microarray studies on effect of Pneumocystis carinii infection on global gene expression in alveolar macrophages

2010-04-12 | GSE20149 | GEO

β-glucans are Masked but Contribute to Pulmonary Inflammation During Pneumocystis Pneumonia

Project description:β-glucans, which can activate innate immune responses, are a major component in the cell wall of the cyst form of Pneumocystis. In the current study we examined whether β-1,3 glucans are masked by surface proteins in Pneumocystis, and what role β-glucans play in Pneumocystis-associated inflammation. For 3 species, including P. jirovecii, which causes Pneumocystis pneumonia (PCP) in humans, P. carinii, and P. murina, β-1,3 glucans were masked in most organisms, as demonstrated by increased exposure following trypsin treatment. Using Q-PCR and microarray techniques, we demonstrated in a mouse model of PCP that treatment with caspofungin, an inhibitor of β-1,3 glucan synthesis, for 21 days, decreased expression of a broad panel of inflammatory markers, including IFN-γ, TNF-α, IL-1β, IL-6, and multiple chemokines/chemokine ligands. Thus, β-glucans in Pneumocystis cysts are largely masked, which likely decreases innate immune activation; this mechanism presumably was developed for interactions with immunocompetent hosts, in whom organism loads are substantially lower. In immunosuppressed hosts with a high organism burden, organism death and release of glucans appears to be an important contributor to deleterious host inflammatory responses.

2016-08-31 | GSE79079 | GEO

Characterizing Pneumocystis carinii centromeres with ChIP-seq

Project description:Characterizing Pneumocystis carinii centromeres with ChIP-seq

| PRJNA940495 | ENA

Pneumocystis carinii B70

Project description:Pneumocystis

| PRJNA223512 | ENA

Pneumocystis carinii B50

Project description:Pneumocystis

| PRJNA223513 | ENA

Pneumocystis carinii B80

Project description:Pneumocystis