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Microsatellite Instability Assessment by Immunohistochemistry in Acute Myeloid Leukemia

ABSTRACT: Microsatellite Instability Assessment by Immunohistochemistry in Acute Myeloid Leukemia: A Reappraisal and Review of the Literature

PROVIDER: PRJEB43843 | ENA |

REPOSITORIES: ENA

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Colorectal cancers with microsatellite instability display unique miRNA profiles

2011-11-22 | GSE30454 | GEO

MicroRNA profiling of human colorectal cancer samples with high microsatellite instability

Project description:Background. Colorectal cancer develops through two main genetic instability pathways characterized by distinct pathologic features and clinical outcome. Results. We investigated colon cancer samples (23 characterized by microsatellite stability, MSS, and 16 by high microsatellite instability, MSI-H) for genome-wide expression of microRNA (miRNA) and mRNA. Based on combined miRNA and mRNA gene expression, a molecular signature consisting of twenty seven differentially expressed genes, inclusive of 8 miRNAs, could correctly distinguish MSI-H versus MSS colon cancer samples. Among the differentially expressed miRNAs, various members of the oncogenic miR-17-92 family were significantly up-regulated in MSS cancers. The majority of protein coding genes were also up-regulated in MSS cancers. Their functional classification revealed that they were most frequently associated with cell cycle, DNA replication, recombination, repair, gastrointestinal disease and immune response. Conclusions. This is the first report that indicates the existence of differences in miRNA expression between MSS versus MSI-H colorectal cancers. In addition, the work suggests that the combination of mRNA/miRNA expression signatures may represent a general approach for improving bio-molecular classification of human cancer.

2007-09-07 | E-TABM-326 | biostudies-arrayexpress

Colorectal cancers with microsatellite instability display unique miRNA profiles

Project description:Analysis of microRNA expression of tumoral and non-tumoral colonic tissues. The aim of this study was to analyze the global miRNA signatures in various groups of well-characterized CRCs based on the presence of microsatellite instability (MSI). Total RNA from formalin-fixed paraffin-embedded tissue blocks from 4 different groups (normal colonic mucosa, Lynch syndrome tumors, sporadic MSI tumors and MSS tumors) was isolated using the RecoverAll Total Nucleic Acid Isolation Kit (Ambion) according to manufacturer instructions. MiRNA expression profiles were analyzed using miRNA microarray platform.

2011-11-22 | E-GEOD-30454 | biostudies-arrayexpress

Microsatellite Instability in Colorectal Cancers

Project description:In this study, we aimed to identify the different histopathological features of tumors with microsatellite instability (MSI) compared to microsatellite stable (MSS) in patients who underwent surgery for colorectal cancer. We also planned to determine how MSI affects prognostic parameters.

| 2398714 | ecrin-mdr-crc

Immunopeptidomic analyses of colorectal cancers with and without microsatellite instability

Project description:Immunopeptidomic analyses of colorectal cancers with and without microsatellite instability

| PRJNA802838 | ENA

Werner Helicase Prevents Cell Death in Cancers with Microsatellite Instability

Project description:Werner Helicase Prevents Cell Death in Cancers with Microsatellite Instability

| PRJNA629771 | ENA

Werner Helicase Prevents Cell Death in Cancers with Microsatellite Instability [PacBio]

Project description:Werner Helicase Prevents Cell Death in Cancers with Microsatellite Instability [PacBio]

| PRJNA645165 | ENA

Werner Helicase Prevents Cell Death in Cancers with Microsatellite Instability (WGS)

Project description:Werner Helicase Prevents Cell Death in Cancers with Microsatellite Instability (WGS)

| PRJNA629786 | ENA

Improved Detection and Identification of Microsatellite Instability Features in Colorectal Cancer

Project description:Improved Detection and Identification of Microsatellite Instability Features in Colorectal Cancer

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Improved Detection and Identification of Microsatellite Instability Features in Colorectal Cancer

Project description:Improved Detection and Identification of Microsatellite Instability Features in Colorectal Cancer

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