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Genotyping-by-sequencing in blackcurrant

ABSTRACT: Genotyping-by-sequencing in blackcurrant (Ribes nigrum)

PROVIDER: PRJEB4532 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR336651.fastq.gz	Fastqsanger.gz
	ERR336652.fastq.gz	Fastqsanger.gz
	ERR336653.fastq.gz	Fastqsanger.gz
	ERR336654.fastq.gz	Fastqsanger.gz
	ERR336655.fastq.gz	Fastqsanger.gz

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Project description:Blackcurrants (Ribes nigrum L., Grossulariaceae) have a high content of anthocyanin polyphenols and these have been shown to have beneficial effects on health, owing to their antioxidant and anti-carcinogenic properties. This study analyzed the constituents of blackcurrant extract (BCE) and investigated its potential phytoestrogenic effects using a breast cancer cell line (MCF-7) overexpressing the estrogen receptor (ER) α. Microarray and ingenuity pathway analysis showed that BCE activated upstream genes such as ERα and transforming growth factor beta 1, and upregulated the expression of many genes downstream of ERα.

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