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ROBO3s: a novel ROBO3 shot isoform promoting breast cancer aggressiveness

ABSTRACT: ROBO3s: a novel ROBO3 shot isoform promoting breast cancer aggressiveness

PROVIDER: PRJEB46393 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR6323260.fastq.gz	Fastqsanger.gz
	ERR6323261.fastq.gz	Fastqsanger.gz
	ERR6323262.fastq.gz	Fastqsanger.gz
	ERR6323263.fastq.gz	Fastqsanger.gz
	ERR6323264.fastq.gz	Fastqsanger.gz

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ROBO3s: a novel ROBO3 shot isoform promoting breast cancer aggressiveness

Project description:ROBO3s: a novel ROBO3 shot isoform promoting breast cancer aggressiveness

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ROBO3s: a novel ROBO3 shot isoform promoting breast cancer aggressiveness

Project description:We identified a novel uncharacterized short isoform of the Roundabout Guidance Receptor 3 (ROBO3) encoding for the C-terminal domain of the protein and lacking transmembrane region. We established an important role for the so-called ROBO3s isoform, mediating cancer stem cell properties by stimulating the Hippo-YAP signaling pathway, and thus driving the resistance of Basal-like breast cancer cells to cytotoxic drugs.

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