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Flagellin

ABSTRACT: Flagellin diversity

PROVIDER: PRJEB47543 | ENA |

REPOSITORIES: ENA

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Dataset's files

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			Action	DRS
	ERR6748430_1.fastq.gz	Fastqsanger.gz
	ERR6748430_2.fastq.gz	Fastqsanger.gz
	ERR6748440_1.fastq.gz	Fastqsanger.gz
	ERR6748440_2.fastq.gz	Fastqsanger.gz
	ERR6748450_1.fastq.gz	Fastqsanger.gz

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Analysis of microRNA expression in murine BMDCs activated by flagellin

Project description:MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression by either translational inhibition or mRNA degradation. However, the role of miRNAs in inflammation induced by flagellin (ligand of TLR5) has not been fully determined, Here, we identified differentially expressed miRNAs in murine bone marrow-derived dendritic cells (BMDCs) between flagellin (FliC) treatment and medium alone using miRNA microarray. And we further evaluated the role of miRNAs in inflammation induced by flagellin.

2021-11-13 | GSE188656 | GEO

An unorthodox flagellin paralog integrates cell cycle and flagellar assembly cues for flagellin translation (Tn-seq)

Project description:How cellular checkpoints couple the orderly assembly of macromolecular machines with cell cycle progression is poorly understood. The alpha-proteobacterium Caulobacter crescentus assembles a single polar flagellum during each cell cycle. We discovered that expression of multiple flagellin transcripts is licensed by a translational checkpoint responsive to a dual input signal: a secretion-competent hook-basal-body (HBB) structure and a surge in the FlaF secretion chaperone during cytokinesis, instructed by the cell cycle circuitry. We find that the unorthodox FljJ flagellin, one of six flagellin paralogs, acts as checkpoint linchpin, binding both FlaF and the FlbT translational regulator. FljJ recruits FlbT to inhibit translation at the 5’ untranslated region in other flagellin transcripts before HBB assembly. Once FlaF is synthesized and stabilized, it directs FljJ secretion through the HBB, thereby separating FlbT from its co-activator and relieving translational inhibition. The FlbT/FlaF pair is wide-spread and functional properties are conserved in alpha-proteobacteria, including pathogens.

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An unorthodox flagellin paralog integrates cell cycle and flagellar assembly cues for flagellin translation (RNA-seq)

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Project description:The study aimed at defining the skin innate responses after intradermal injection of flagellin. For this purpose, pigs were immunized by intradermal route with flagellin and H1N1 antigen. Skin was then sampled for microarray analyses.

2016-01-31 | GSE72256 | GEO

mpk6 - Flagellin response in mpk mutants

Project description:au-09-01_mpk_flagellin_edu - mpk6 - Investigate flagellin mpk dependent genes - Comparision between mpk6 and Col-0 seedlings. Keywords: gene knock out

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bak1bkk1 - Flagellin response in mpk mutants

Project description:au-09-01_mpk_flagellin_edu - bak1bkk1 - Investigate flagellin mpk dependent genes by comparision between bak1bkk1 and col-0. Keywords: gene knock out

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mpk3 - Flagellin response in mpk mutants

Project description:au-09-01_mpk_flagellin_edu - mpk3 - Investigate flagellin mpk dependent genes - Comparisions between mpk3 and Col-0. 2 weeks seedlings. Keywords: wt vs mutant comparison

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transcriptome analysis of dgk5 mutant in response to flagellin-Transcriptome analysis of dgk5 mutant

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Project description:Most Eukaryotes recognise flagellin as a signature of bacterial invasion. In contrast to animals, plants do not recognise flagellin proteins, but conserved peptides released from flagellin (Felix et al., 1999). However, these peptides (e.g. flg22) are folded and buried deeply inside the flagellin polymer and would need to be released before they can interact with cell surface receptors, such as FLS2 (Fliegman & Felix, 2016). Here we discovered that the hydrolytic pathway releasing the flagellin elicitor in plants is initiated by a host-secreted beta-galactosidase (BGAL), which removes the terminal modified viosamine (mVio) from the O-glycan that cloaks the flagellin polymer. BGAL contributes to flagellin-dependent immunity but only against bacterial Pseudomonas syringae strains that carry mVio. Signatures of arms races at this new level of antagonistic interactions are that BGAL is suppressed during infection by a heat stable metabolite secreted by bacteria, and that other P. syringae strains carry BGAL-insensitive O-glycans.

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