Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

E. marmotae causing invasive infections

ABSTRACT: E. marmotae causing invasive infections

PROVIDER: PRJEB47670 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other
	CAKAEI01.dat.gz	Other
	CAKAEI01.fasta.gz	Fasta.gz
	CAKAEI01.master.dat	Other
	CAKAEJ01.dat.gz	Other

Items per page:

1 - 5 of 26

Similar Datasets

Genotyping by array of Pseudomonas aeruginosa strains causing chronic or acute infections in humans

Project description:Genotyping of 182 Pseudomonas aeruginosa strains causing chronic or acute infections to humans

2012-08-02 | E-MTAB-1108 | biostudies-arrayexpress

Enhanced Monocyte Response & Decreased Central Memory T Cells in Children with Invasive Staphylococcus aureus Infections

Project description:Staphylococcus aureus has emerged as a significant pathogen causing severe, invasive disease in otherwise healthy people. Despite considerable advances in understanding the epidemiology, resistance mechanisms, and virulence factors produced by the bacteria, there is limited knowledge of the in vivo host immune response to acute, invasive S. aureus infections. Herein, we report that peripheral blood mononuclear cells from patients with severe S. aureus infections demonstrate a distinctive and robust gene expression profile which is validated in a distinct group of patients and on a different microarray platform. Application of a systems-wide modular analysis framework reveals significant over-expression of innate immunity genes and under-expression of genes related to adaptive immunity. Simultaneous flow cytometry analyses demonstrated marked alterations in immune cell numbers, with decreased central memory CD4 and CD8 T cells and increased number of monocytes. CD14+ monocyte numbers significantly correlated with the gene expression levels of genes related to the innate immune response. These results demonstrate the value of applying a systems biology approach that reveals the significant alterations in the components of circulating blood lymphocytes and monocytes in invasive S. aureus infections.

2009-05-30 | GSE16129 | GEO

Escherichia marmotae

Project description:Escherichia marmotae overview

| PRJNA429864 | ENA

S. pyogenes isolates causing invasive disease in England

Project description:Two S. pyogenes isolates causing invasive disease in England 2019

| PRJEB36425 | ENA

Streptococcus pyogenes emm1 causing invasive disease in Belgium (2020-2023)

Project description:Streptococcus pyogenes emm1 causing invasive disease in Belgium (2020-2023)

| PRJEB64886 | ENA

Escherichia marmotae

Project description:Escherichia marmotae Genome sequencing and assembly

| PRJNA1048383 | ENA

Escherichia marmotae

Project description:Escherichia marmotae Genome sequencing and assembly

| PRJNA730693 | ENA

Escherichia marmotae

Project description:Escherichia marmotae Genome sequencing and assembly

| PRJNA1049744 | ENA

Escherichia marmotae strain:E690

Project description:Escherichia marmotae E690

| PRJNA632731 | ENA

Integrative genomic, virulence, and transcriptomic analysis of emergent Streptococcus dysgalactiae subspecies equisimilis (SDSE) emm type stG62647 isolates causing human infections

Project description:Streptococcus dysgalactiae subspecies equisimilis (SDSE) is a Gram-positive bacterial pathogen that infects humans and is closely related to group A streptococcus (GAS). Compared to GAS, far less is known about SDSE pathobiology. Increased rates of invasive SDSE infections have recently been reported in many countries. One SDSE emm type, stG62647, is known to cause severe diseases, including necrotizing soft-tissue infections, endocarditis, and osteoarticular infections. To increase our understanding of the molecular pathogenesis of stG62647 SDSE isolates causing human infections, we sequenced to closure the genomes of 120 stG62647 SDSE isolates. The genomes varied in size from 2.1 to 2.24 megabase pairs. Consistent with previous data, the great majority of stG62647 isolates had IS1548 integrated into the silB gene, thereby inactivating it. Regions of difference in gene content, including putative mobile genetic elements, were the largest source of genomic diversity. All 120 stG62647 isolates were assayed for virulence using a well-established mouse model of necrotizing myositis. An unexpectedly wide range of virulence was identified (20% to 95%), as assessed by near-mortality data. To explore the molecular mechanisms underlying virulence differences, we analyzed RNAseq transcriptome profiles for 38 stG62647 isolates (comprising the 19 least and most virulent) grown in vitro. Genetic polymorphisms were identified from whole-genome sequence data. Collectively, the results suggest that these SDSE isolates use multiple genetic pathways to achieve an altered virulence phenotype. Our study integrates genomic, mouse virulence, and RNAseq data to advance our understanding of SDSE pathobiology and its molecular pathogenesis.

2024-07-20 | GSE272047 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data