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Grippe

ABSTRACT: Lung microbiota but not mycobiota predicts day 28 mortality in critically ill influenza patients: a feasibility study

PROVIDER: PRJEB48645 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR7250670_1.fastq.gz	Fastqsanger.gz
	ERR7250670_2.fastq.gz	Fastqsanger.gz
	ERR7250680_1.fastq.gz	Fastqsanger.gz
	ERR7250680_2.fastq.gz	Fastqsanger.gz
	ERR7250690_1.fastq.gz	Fastqsanger.gz

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Grippe

Project description:Lung microbiota but not mycobiota predicts day 28 mortality in critically ill influenza patients: a feasibility study

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Grippe

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Grippe

Project description:Lung microbiota but not mycobiota predicts day 28 mortality in critically ill influenza patients: a feasibility study

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Early predictive factors of mortality in onco-hematology patients admitted to the Intensive Care Unit for septic shock: A proteomic approach.

Project description:The number of organ failures at intensive care unit (ICU) admission is the main prognostic factor in septic shock. The aim was to assess classical clinico-biological parameters evaluating organ dysfunctions at ICU admission, combined with proteomics analysis, on day-30 mortality in critically ill onco-hematology patients admitted to the ICU for septic shock.

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Project description:We found that a dose of influenza (5,000 pfu of recombinant influenza A/WSN/33 (rWSN) H1N1 virus strain) that resulted in 50% mortality in wildtype littermate control mice showed minimal mortality in Irgm1-/- mice, indicating that Irgm1 deficiency was protective during influenza infection. This protective effect was dependent on the Type I interferon receptor Ifnar. We performed transcriptional profiling to identify molecular mechanisms associated with protection from influenza infection in Irgm1-/- lung. Both male and female mice were used at 8-12 weeks of age. Lung gene expression was assessed by RNA-seq at the following times post-influenza infection: Day 3 (early time point, early histological damage present in control mice), Day 6 (intermediate time point, late histological damage present in control mice) and Day 10 (late time point, morbidity and mortality present in control mice).

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