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Colorectal microbiota after removal of colorectal cancer

ABSTRACT: The study investigates the microbiota of colorectal cancer patients post surgery

PROVIDER: PRJEB48823 | ENA |

REPOSITORIES: ENA

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Colorectal microbiota after removal of colorectal cancer

Project description:The study investigates the microbiota of colorectal cancer patients post surgery

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Comparing the microbiota composition of stool, intestinal biopsy and saliva between patients with Adenoma and Adenocarcinoma

Project description:Increasing importance in the onset and progression from colonic adenomatous polyps (AP) to colorectal cancer (CRC) has been attributed to the gut microbiota and the oncometabolites they may produce. To comprehensively study the microbial spatial variations and role of microbiota in CRC progression, multiple niches from the gastrointestinal system have to be investigated. We collected saliva, tissue and stool samples from 61 patients, including 46 CRC patients and 15 AP patients, well matched in age and sex, who were undergoing surgery in 2018 at the Careggi University Hospital (Florence, Italy). For all samples and locations we surveyed microbial composition through 16S ribosomal RNA and metabolites using NMR, and compared them across tissues and disease state, also considering CRC TNM staging. Our result suggest the importance of microbiota communities and derived oncometabolites in CRC development. Such association can be a forerunner for future studies on CRC/AP management.

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Metaproteomics characterizes human gut microbiota function in colorectal cancer

Project description:Alterations in gut microbiota have been implicated in the pathogenesis of Colorectal Cancer (CRC). Here we collected fecal samples from 14 CRC patients and 14 healthy volunteer cohorts, and characterized their microbiota using label-free quantitative metaproteomics method. We have quantified 30,062 gut microbial protein groups, 91，902 peptides, and 195 genera of microbes, among which 341 proteins were found significantly different in abundance between the CRC patients and healthy volunteers. Our study demonstrates that gut bacteria involve in CRC pathogenesis not only via taxonomy abundance variations but also functional activity changes.

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miRNA array in colorectal carcinoma

2011-11-29 | GSE33961 | GEO

miRNA array in colorectal carcinoma

Project description:To search for potential miRNAs associated with prognosis in colorectal carcinoma, miRNA expression profiles were analyzed in patients with stage III colorectal carcinoma. miRNA expression levels were compared between long and short time survival after surgery with standard chemotherapy. Two groups of colorectal carcinoma tissues for miRNA array. Long time (L) survival (≥5 years) group and short time survival (S) (<5 years) group.

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Analysis of the microbiota composition of colorectal mucosa tissues and adjacent healthy tissues of 40 patients affected by colorectal cancer.

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Project description:The long term microbiota and metabolic status in patients with colorectal cancer after curative colon surgery

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Gene expression data of 135 patients presenting colorectal adenoma

Project description:Gene expression profiles of 135 patients presenting with colorectal adenomas during surgery or colonoscopy were obtained using Affymetrix U133+ arrays.

2018-12-01 | GSE117607 | GEO

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