Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Angiostrongylus costaricensis Genome sequencing

ABSTRACT: Genomic assembly of nematode Angiostrongylus costaricensis, as part of the 50 Helminth Genomes Initiative sequencing of the parasitic worms that have the greatest impact on human, agricultural and veterinary disease and cause significant global health issues particularly in the developing world, or those used as model organisms.

PROVIDER: PRJEB494 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Angiostrongylus costaricensis

Project description:Angiostrongylus costaricensis overview

| PRJNA261755 | ENA

Angiostrongylus costaricensis strain:Crissiumal

Project description:Angiostrongylus costaricensis strain:Crissiumal Raw sequence reads

| PRJNA851259 | ENA

Identification of novel genes and proteoforms in Angiostrongylus costaricensis through a proteogenomic approach

Project description:Data from multiple high throughput technologies such as RNA sequencing (RNA-Seq) and protein mass spectrometry (MS/MS) are often used to assist in predicting eukaryote genome features such as genes, splice variants, and single nucleotide variants (SNVs). The genomes of parasitic nematodes causing neglected tropical diseases are often poorly annotated. Angiostrongylus costaricensis, a nematode that causes an intestinal inflammatory disease known as abdominal angiostrongyliasis (AA), is one example. Currently, no drugs or treatments are available for AA, a public health problem in Latin America, especially in Costa Rica and Brazil. The available genome of A. costaricensis, specific to the Costa Rica strain, is a draft version not supported by transcript- or protein-level evidence. This study used RNA-Seq and MS/MS data to perform an in-depth annotation of the A. costaricensis genome. Our prediction supplemented the reference annotation with a) novel coding and non-coding genes; b) pieces of evidence of alternative splicing generating new proteoforms; c) a list of SNVs specific to the Brazilian strain (Crissiumal). To the best of our knowledge, this is the first time that a multi-omics approach has been used to improve the genome annotation of a parasitic nematode. We hope this supplemented genome annotation can assist the future development of drugs to treat AA caused by either Brazil strain (Crissiumal) or Costa Rica strain.

2023-03-11 | PXD034605 | Pride

Activity profiling of peptidases in Angiostrongylus costaricensis first-stage larvae and adult worms

Project description:Angiostrongylus costaricensis is a relatively uncharacterized nematode that causes abdominal angiostrongyliasis in Latin America, a human parasitic disease. Currently, no effective pharmacological treatment for angiostrongyliasis exists. Peptidases are known to be druggable targets for a variety of diseases and are essential for several biological processes in parasites. Therefore, this study aimed to systematically characterize the peptidase activity of A. costaricensis in different developmental stages of this parasitic nematode.

2018-08-21 | MSV000082836 | MassIVE

Angiostrongylus cantonensis Genome sequencing

Project description:Genomic assembly of nematode Angiostrongylus cantonensis, as part of the 50 Helminth Genomes Initiative sequencing of the parasitic worms that have the greatest impact on human, agricultural and veterinary disease and cause significant global health issues particularly in the developing world, or those used as model organisms.

| PRJEB493 | ENA

Gene expression profile of mouse infected by Angiostrongylus cantonensis

Project description:Infection by Angiostrongylus cantonensis accounted for the meningitis characterized by accumulation of eosinophils in non-permissive host like mouse and human. However, the underlying molecular basis is still obscure. To uncover the specific molecular mechanism responsible for the meningitis caused by Angiostrongylus cantonensis, we carried out gene expression array for mouse brain with infection by Angiostrongylus cantonensis.

2020-10-14 | GSE159486 | GEO

Touit costaricensis

Project description:Touit costaricensis

| PRJNA491352 | ENA

Arremon costaricensis

Project description:Arremon costaricensis

| PRJNA920038 | ENA

Zentrygon costaricensis

Project description:Zentrygon costaricensis overview

| PRJNA977314 | ENA

Angiostrongylus cantonensis

Project description:Angiostrongylus cantonensis