Project description:Generation of in vitro models of cancer stem cells for in vivo xenograft models. hiPSC differentiation into a desired tissue allows studying physiologic processes in human-relevantcell systems. By introducing disease-specific mutations, these cells allow studying genetic origins of diseases in a tissue-specific manner.
Project description:Generation of in vitro models of cancer stem cells for in vivo xenograft models. hiPSC differentiation into a desired tissue allows studying physiologic processes in human-relevantcell systems. By introducing disease-specific mutations, these cells allow studying genetic origins of diseases in a tissue-specific manner.
Project description:Generation of in vitro models of cancer stem cells for in vivo xenograft models. hiPSC differentiation into a desired tissue allows studying physiologic processes in human-relevantcell systems. By introducing disease-specific mutations, these cells allow studying genetic origins of diseases in a tissue-specific manner.
Project description:Human induced pluripotent stem cell (hiPSC)-derived endothelial cells were transplanted into mouse liver and isolated at several time-points to assess their developmental profile over time. They were compared to in vitro hiPSC-endothelial cells, and primary human liver sinusoidal endothelial cells (either freshly isolated or expanded in culture).