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OralMicrobiomeFanconi

ABSTRACT: Impact of the local oral microbiome in the pathogenesis of oral carcinoma in Fanconi anemia patients

PROVIDER: PRJEB5069 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR385803.fastq.gz	Fastqsanger.gz
	ERR385804.fastq.gz	Fastqsanger.gz
	ERR385805.fastq.gz	Fastqsanger.gz
	ERR385806.fastq.gz	Fastqsanger.gz
	ERR385807.fastq.gz	Fastqsanger.gz

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Project description:Oral Microbiome in Fanconi Anemia

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Transcription profiling of human bone marrow cells from normal volunteers and from children and adults with Fanconi anemia

Project description:Fanconi anemia (FA) is a rare inherited disease complicated by aplastic anemia. There is evidence that hematopoietic stem cells have lost self replicative capacity and undergo apoptosis when exposed to inhibitory cytokines including interferon gamma and tumor necrosis factor-alpha. We used gene expression microarrays to identify transcriptomal differences between bone marrow cells from normal volunteers and from children and adults with Fanconi anemia Experiment Overall Design: Fanconi anemia patients were identified using mitomycin C and/or diepoxybutane chromosomal breakage analysis. Eleven normal volunteers and 21 FA patients were studied. All FA patients with cytogenetic evidence of clonal evolution were excluded. All FA patients with acute leukemia were excluded. RNA was prepared from freshly obtained low density mononuclear cell fractions.

2009-09-18 | E-GEOD-16334 | biostudies-arrayexpress

Restored Hematopoietic Stem Cell Transcriptional Program in Fanconi Anemia Patients Following Gene Therapy

Project description:The effect of gene therapy in the Hematopoietic stem cells of patients with fanconi anemia has been analyzed. For this purpose 3 fanconi patients bone marrow and a healthy one has been aspirated and CD34+ cells sorted. The data was processed using the usual 10X protocol

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Gene expression based identification of potential genes involved in Fanconi anemia

Project description:Fanconi anemia is a rare inherited hematological disorder which commonly presents with bone marrow failure, developmental abnormalities and susceptibility to cancer with high rates of prevalence in ethnic populations. The objective of this study was to identify potential genes that aid in the progression of the disease or produce its principal symptoms and to hypothesize enabling roles for certain genes that are not part of the central molecular machinery causing the disease. A total of 2 Fanconi anemia samples were collected from patients who displayed characteristic FA features. All of them gave positive results for the DNA breakage test after mitomycin C treatment. Samples were referred by Dr. Sheila Mohan of REFAIN (Registry for Fanconi anemia in India). Whole genome microarray analysis of peripheral blood from 2 patient samples and one normal individual. Sequential analysis of microarray data was carried out using gene ontology and pathway analysis to identify candidate genes.

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Project description:Whole genomic sequencing of Chinese Fanconi anemia patients

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Expression data from normal and Fanconi anemia low density bone marrow cells

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Project description:EMG produced TPA metagenomics assembly of PRJNA542280 data set (Oral Microbiome in Fanconi Anemia).

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Project description:oral microbiome of oral squamous cell carcinoma patients

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