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ESBL-sharing

ABSTRACT: Healthy companion animals and owners colonisation and sharing of ESBL/AmpC-producing Enterobacterales, Portugal and United Kingdom

PROVIDER: PRJEB51686 | ENA |

REPOSITORIES: ENA

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Dataset's files

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			Action	DRS
	ERR9355100_1.fastq.gz	Fastqsanger.gz
	ERR9355100_2.fastq.gz	Fastqsanger.gz
	ERR9355101_1.fastq.gz	Fastqsanger.gz
	ERR9355101_2.fastq.gz	Fastqsanger.gz
	ERR9355102_1.fastq.gz	Fastqsanger.gz

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LC-MS/MS analysis demonstrates a decrease in porins and increase in CMY-2-like beta-lactamases in E. coli exposed to meropenem

Project description:While ESBL and AmpC beta-lactamases barely degrade carbapenems, they are able to bind them and prevent them from interacting with penicillin binding proteins thereby preventing their effect. When these beta-lactamases are expressed at a high level and combined with a decreased influx of carbapenems due to a decrease in membrane permeability, Enterobacterales can become resistant to carbapenems. In this study we developed a LC-MS/MS assay for the detection of the E. coli porins OmpC and OmpF, it’s chromosomal AmpC beta-lactamase and the plasmid-mediated CMY-2 beta-lactamase. Subsequently, we cultured CMY-2 positive E. coli isolates in the presence of meropenem and analyzed mutants that showed increased resistance to meropenem using our developed assay and western blot. In all five selected strains, a decrease in OmpC and/or OmpF was the first event towards an increase in meropenem minimum inhibitory concentrations (MICs). Subsequently, in four of the five isolate series, MICs increased further after an increase in CMY-2-like production.

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Project description:ESBL Enterobacterales from Companion Animals Raw sequence reads

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