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Strongyloides papillosus Genome sequencing

ABSTRACT: Genomic assembly of nematode Strongyloides papillosus, as part of the 50 Helminth Genomes Initiative sequencing of the parasitic worms that have the greatest impact on human, agricultural and veterinary disease and cause significant global health issues particularly in the developing world, or those used as model organisms.

PROVIDER: PRJEB525 | ENA |

REPOSITORIES: ENA

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Strongyloides papillosus

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Strongyloides stercoralis Genome sequencing

Project description:Genomic assembly of nematode Strongyloides stercoralis, as part of the 50 Helminth Genomes Initiative sequencing of the parasitic worms that have the greatest impact on human, agricultural and veterinary disease and cause significant global health issues particularly in the developing world, or those used as model organisms.

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Comparison of transcriptional profiles from 2W1S-specific CD4+ T cells during 2W1S-expressing Salmonella and Strongyloides ratti infections reveals that infectious context drives effector CD4+ T cell function

Project description:Approximately one-third of the world is infected with parasitic helminths, and there are no available vaccines. Helminths induce robust type 2 immune responses and host CD4+ T cells are required for clearance, but how helminth-specific CD4+ T cells are generated and whether they adopt prototypical features of effector Th2 cells is entirely unknown. We generated a novel transgenic line of Strongyloides ratti to track and study helminth-specific T cells. This transgenic line, termed Hulk, stably expresses immunodominant T cell epitope 2W1S as a fusion protein with FLAG and green fluorescent protein (GFP). We consistently observe expansion of CD44hiCD11ahi 2W1S-specific CD4+ T cells in the lungs of Hulk-infected C57BL/6 mice. Surprisingly, these cells do not exhibit a Th2 or regulatory T cell (Treg) phenotype, and their expansion is minimal compared to expansion following 2W1S-peptide immunization. In order to more thoroughly interrogate the phenotype and function of 2W1S-specific CD4+ T cells during Hulk infection, we performed mRNA sequencing on 2W1S-specific CD4+ T cells from both Hulk-infected and 2W-Salmonella-infected mice. Interestingly, whereas 2W1S-specific CD4+ T cells that expand during 2W-Salmonella infection express canonical pro-inflammatory genes, 2W1S-specific CD4+ T cells from Hulk-infected mice preferentially upregulate genes associated with immune suppression and wound healing. Altogether, these data suggest that helminth antigen specific CD4+ T cells may comprise an unconventional subset that mediates immunosuppression and tissue repair following helminth infection and not necessarily type 2 cytokine responses.

2021-06-18 | GSE134278 | GEO

Progresses and challenges of Strongyloides spp. proteomics

Project description:The availability of high-quality data of helminth genomes provided over the last two decades has supported and accelerated large-scale ‘omics studies and, consequently, the achievement of a more in depth molecular characterisation of a number of pathogens. Strongyloides spp. are no less and since their genome was made available transcriptomics has been rather frequently applied to investigate gene expression regulation across their life cycle. Strongyloides proteomics characterisation has instead been somehow neglected, with only a few reports performing high-throughput or targeted analyses associated with protein identification by tandem mass spectrometry. Such investigations are however necessary in order to discern important aspects associated with human strongyloidiasis, including understanding parasite biology and the mechanisms of host-parasite interaction, but also to identify novel diagnostic and therapeutic targets. In this review article we will give an overview of the published proteomics studies investigating strongyloidiasis at different levels, spanning from the characterisation of the somatic proteome and excretory/secretory products of different parasite stages to the investigation of potentially immunogenic proteins. Moreover, in the effort to try to start filling the current gap in host-proteomics, we will also present the first serum proteomics analysis in patients suffering from human strongyloidiasis.

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Strongyloides venezuelensis

Project description:Strongyloides venezuelensis transcriptome

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Strongyloides stercoralis

Project description:Strongyloides stercoralis overview

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Strongyloides stercoralis

Project description:Strongyloides stercolaris genome variation

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Transcriptome sequencing of Strongyloides ratti

Project description:Strongyloides ratti is a common gastro-intestinal parasite of the rat. The adult parasites are female only, about 2mm long and live in the mucosa of the small intestine. These parasites produce eggs that pass out of the host in its faeces. In the environment infective larval stages develop either directly or after a facultative sexual free-living adult generation. Infective larvae infect hosts by skin penetration.S. ratti is the laboratory analogue of the parasite of humans, S. stercoralis. S. stercoralis is a wide-spread parasite of humans, occurring principally in the tropics and sub-tropics: some 100-200 million people are infected worldwide. Infection of immunosuppressed individuals can result in disseminated strongyloidiasis, in which worms occur throughout the body. This can be fatal unless anti-Strongyloides therapy is given. Other species of Strongyloides parasitise a wide range of vertebrates. As part of the Strongyloides ratti genome project we are profiling the transcriptome of the parasite across its life cycle using RNA-Seq.. This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see http://www.sanger.ac.uk/datasharing/

2013-01-28 | E-ERAD-92 | biostudies-arrayexpress

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