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Competitive regulation of HOPX transcription governs cardiomyocyte maturation

ABSTRACT: Competitive regulation of HOPX transcription governs cardiomyocyte maturation

PROVIDER: PRJEB52787 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR9717290.fastq.gz	Fastqsanger.gz
	ERR9717286.fastq.gz	Fastqsanger.gz
	ERR9717287.fastq.gz	Fastqsanger.gz
	ERR9717288.fastq.gz	Fastqsanger.gz

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Competitive regulation of HOPX transcription governs cardiomyocyte maturation

Project description:This study establishes the homeodomain only protein, HOPX, as a determinant controlling the molecular switch between cardiomyocyte progenitor and maturation gene programs. This dataset is about time-course CAGE (capped analysis of gene expression) data with genome-wide active transcription footprinting. HOPX CRISPRi cells were differentiated into cardiomyocytes ± DOX and analyzed by CAGE sequencing, among other methods. The study revealed that HOPX interacts with and controls core cardiac networks by regulating the activity of mutually exclusive developmental gene programs.

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Persistence of effector memory Th1 cells is regulated by the homeobox only protein Group1 Hopx-/-, Group2 Hopx+/-, Group3 Hopx+/+

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