Project description:Diversity clinical phenotypes of autism spectrum disorders (ASD), caused by heterogeneity of genetic and environmental factors, hampered the investigation in uncovering pathological mechanisms. Here we generated ASD patient-cerebral organoids from induced pluripotent stem cells (iPSCs) that reprogramed from the early-onset ASD individuals at around 2 years old with common clinical diagnosis in a prospective birth cohort, which was excluded typical autistic mutations and environmental exposures.
Project description:To characterize the human umbilical cord plasma (UCP) microtranscriptome profile at birth, we sequenced microRNAs in UCP samples collected at delivery, between the 34th and the 42th weeks of pregnancy (mean gestationnal age at birth: 39.3 ± 1.3 weeks), from 286 newborns from the Gen3G cohort. We then performed association analyses to assess the microRNA profile correlation with birth-related biological factors, maternal and fetal exposomes as well as factors related to early-life adiposity programming.
Project description:CIDR Preterm Birth Boston Cohort
| PRJNA75541 | ENA
Project description:Early-life gut microbiome and behavioral development: Rio Birth Cohort Study of Environmental Exposure and Childhood Development (PIPA Project)
Project description:There is extensive variation in DNA methylation between individuals and ethnic groups. These differences can arise from a combination of genetic and non-genetic influences and potential modifiers include nutritional cues, early life experience, and social and physical environments. Here we have assayed genome-wide DNA methylation in neonatal cord blood from African American, European American, and other ancestral groups. This is part of the CANDLE Study (Conditions Affecting Neurocognitive Development and Learning in Early Childhood). Our overarching goal is to determine the different environmental and maternal factors that can modify DNA methylation in newborns. This is a cross-sectional study of a total of 216 racially diverse participants of CANDLE. Cordblood was collected at birth. DNA methylation was measured using the Illumina HumanMethylation27 BeadChip. Based on maternal self-report, the samples are 112 African Americans, 91 European Americans and 13 other racial or mixed race group.