Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: Association of MTR gene polymorphisms and congenital heart disease

PROVIDER: PRJEB54935 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	re--SNPdataofMTR.vcf.csi	Other
	re--SNPdataofMTR.vcf.gz	Vcf

Items per page:

1 - 2 of 2

Similar Datasets

Proteomic analysis of the umbilical cord in prematurity and congenital heart disease

Project description:Data-independent acquisition (DIA)-based proteome analysis in preterm infants and congenital heart disease infants

2024-12-20 | PXD047992 | JPOST Repository

Maternal Folate Genes and Aberrant DNA Hypermethylation among Offspring with Pediatric Lymphoblastic Leukemia

Project description:Pediatric acute lymphoblastic leukemia (ALL) is believed to originate in utero and frequently involves aberrant promoter methylation. Folate is the methyl donor for DNA methylation, suggesting that maternal folate metabolism may contribute to the development of ALL. We previously reported significant associations between single nucleotide polymorphisms (SNPs) in the maternal methionine synthase (MTR) gene and offspring’s risk of ALL. Here, we test the associations of 11 SNPs in MTR with aberrant DNA methylation in offspring with ALL. We recruited 51 ALL case-mother pairs from Texas Children’s Hospital from 2005-2010. We collected maternal saliva samples and diagnostic bone marrow plasma from cases. Bone marrow plasma was obtained from six healthy donors. DNA methylation was determined using MCA-Seq. Pyrosequencing was used to determine maternal MTR genotypes. We identified offspring with high and low promoter methylation and used logistic regression to estimate the effects of maternal genotype on offspring methylation. Twenty-two cases (43%) demonstrated high promoter methylation. Maternal MTR 113A>G was associated with aberrant DNA methylation in offspring (OR 4.59, 95% CI 1.21-17.93). To the best of our knowledge, this is the first report of an association between maternal genotype and offspring methylation in pediatric ALL.

2018-05-03 | GSE99793 | GEO

Project description:Association of maternal BHMT and BHMT2 gene polymorphism and congenital heart disease in offspring

| PRJEB51904 | ENA

Project description:Pathogenesis of congenital heart disease

| PRJNA563970 | ENA

Homo sapiens

Project description:Array CGH in congenital heart disease

| PRJNA99395 | ENA

Mus musculus

Project description:NK2 model of congenital heart disease

| PRJNA85533 | ENA

Nono deficiency impedes the proliferation and adhesion of H9c2 cardiomyocytes through Pi3k/Akt signaling pathway [ATAC-seq]

Project description:Purpose: Congenital heart disease (CHD) is the most common type of birth defect and the main noninfectious cause of death during the neonatal stage. Currently, hemizygous loss-of-function variants in NONO(The non-POU domain containing, octamer-binding) gene have been described as the cause of congenital heart defects in males. However, the effects of NONO on cardiac development have not been fully elucidated.

2023-05-01 | GSE211403 | GEO

PCGC: Congenital Heart Disease Genetic Network Study

Project description:PCGC: Congenital Heart Disease Genetic Network Study

| PRJNA183421 | ENA

Homo sapiens

Project description:PCGC: Congenital Heart Disease Genetic Network Study

| PRJNA183422 | ENA

Developmental Mechanisms of Human Congenital Heart Disease

Project description:Developmental Mechanisms of Human Congenital Heart Disease

| PRJNA380445 | ENA