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Orally administrated EPS-AN8 mediated protection from cadmium harmfulness in DA rats

ABSTRACT: EPS-AN8 protection of Cd toxicity in rats

PROVIDER: PRJEB56180 | ENA |

REPOSITORIES: ENA

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			Action	DRS
		Other
	ERR10228700_1.fastq.gz	Fastqsanger.gz
	ERR10228700_2.fastq.gz	Fastqsanger.gz
	ERR10228702.fastq.gz	Fastqsanger.gz
	ERR10228702_1.fastq.gz	Fastqsanger.gz

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Orally Administrated <i>Lactiplantibacillus plantarum</i> BGAN8-Derived EPS-AN8 Ameliorates Cd Hazards in Rats.

Project description:Cadmium (Cd) is a highly toxic metal that is distributed worldwide. Exposure to it is correlated with a vast number of diseases and organism malfunctions. Exopolysaccharides (EPS) derived from Lactiplantibacillus plantarum BGAN8, EPS-AN8, previously showed great potential for the in vitro protection of intestinal cells from this metal. Here, we investigated the potential of food supplemented with EPS-AN8 to protect rats from the hazardous effects of Cd exposure. After thirty days of exposure to lower (5 ppm) and higher (50 ppm)-Cd doses, the administration of EPS-AN8 led to decreased Cd content in the kidneys, liver, and blood compared to only Cd-treated groups, whereas the fecal Cd content was strongly enriched. In addition, EPS-AN8 reversed Cd-provoked effects on the most significant parameters of oxidative stress (MDA, CAT, GST, and GSH) and inflammation (IL-1β, TNF-α, and IFN-γ) in the duodenum. Moreover, micrographs of the duodenum were in line with these findings. As the gut microbiota has an important role in maintaining homeostasis, we used 16S rRNA amplicon sequencing and investigated the effects of Cd and EPS-AN8 on one part of the microbiota presented in the duodenum. Although Cd decreased the growth of lactobacilli and mostly favored the blooming of opportunistic pathogen bacteria, parallel intake of EPS-AN8 reversed those changes. Therefore, our results imply that EPS-AN8 might be extremely noteworthy in combatting this toxic environmental pollutant.

| S-EPMC9917968 | biostudies-literature

Lacticaseibacillus paracasei strain:EPS DA-BACS

Project description:Lacticaseibacillus paracasei strain:EPS DA-BACS Genome sequencing and assembly

| PRJNA880719 | ENA

Bifidobacterium bifidum strain:EPS DA-LAIM

Project description:Bifidobacterium bifidum strain:EPS DA-LAIM Genome sequencing and assembly

| PRJNA880695 | ENA

Bifidobacterium bifidum strain:EPS DA-LAIM

Project description:Bifidobacterium bifidum strain:EPS DA-LAIM Genome sequencing and assembly

| PRJNA880711 | ENA

Lacticaseibacillus paracasei strain:EPS DA-BACS

Project description:Lacticaseibacillus paracasei strain:EPS DA-BACS Genome sequencing and assembly

| PRJNA880699 | ENA

Transcriptome analyses of in vitro exercise by EPS and adrenaline

Project description:To evaluate transcriptomic changes induced by in vitro exercise, we established two in vitro exercise models; EPS (electrical pulse stimulation and clenbuterol treatment). As for clen-buterol treatment, differentiated C2C12 myotubes were treated by 30 ng/ml clenbuterol for 1 hour and control and clenbuterol treated C2C12 myotubes were analyzed by RNA-sequencing. As for an EPS model, EPS was applied to differentiated C2C12 myotubes for 24 hours and control and EPS applied C2C12 myotubes were analyzed by RNA-sequencing.

2021-11-06 | GSE183159 | GEO

A long noncoding RNA lincRNA-EPS acts as a transcriptional brake to restrain inflammation

Project description:LincRNA-EPS is a long noncoding RNA that is expressed in macrophages and downregulated upon exposure to diverse microbial products. Analysis of macrophages from lincRNA-EPS-deficient mice revealed a specific role for this lincRNA in restraining immune response gene (IRG) expression. Mechanistically, lincRNA-EPS associates with chromatin at regulatory regions of IRGs to repress their transcription. To gain insight into the molecular function of lincRNA-EPS on chromatin, we generated ATAC-Seq libraries from wildtype and lincRNA-EPS-deficient macrophages stimulated with LPS.

2016-05-08 | GSE78873 | GEO

Gene expression changes induced in Rice (Oryza sativa) leaves following treatment with any one of the following: wild type Xoo, lipopolysaccharide (LPS) and exopolysaccaride (EPS) deficient Xoo mutant; LPS proficient but EPS deficient Xoo mutant

Project description:Lipopolysaccharide is a Microbe Associated Molecular Pattern (MAMP) that is known to induce defense responses in plants. In rice we have shown that Xoo LPS induce callose deposition, reactive oxygen production and induced resistance response. The exopolysaccaride (EPS) secreted by Xoo might be involved in supressing these defense responses. We have performed transcriptional profiling of rice leaf gene expression changes after treatment with Xoo strains BXO1003 (LPS-, EPS-), BXO1002 (LPS+ EPS-) and BXO43 (wild type) along with milliQ treated leaves to identify the genes that are differentially expressed. RNA was isolated from mid veins of rice leaves 15 hours after injecting them with Xoo strains BXO1003 (LPS-, EPS-), BXO1002 (EPS-), BXO43 (wild type) or milli-Q water. The rice gene expression in each of the treatment was normalized based on the gene expression in the milli-Q treatment.

2015-06-30 | E-GEOD-61833 | biostudies-arrayexpress

Variovorax paradoxus EPS

Project description:Variovorax paradoxus EPS genome sequencing project

| PRJNA43457 | ENA

Bif EPS samples

Project description:Bif EPS samples Raw sequence reads

| PRJNA480119 | ENA