Project description:Pro-IL-1a is a pro-inflammatory cytokine that is localised to the nucleus in humans due to the presence of a nuclear localisation sequence in its pro-domain. However, some mammals have a predicted loss of fucntion to their nuclear localistion sequence. It is suggested that pro-IL-1a serves as a dual action protein, and that in addition to its role as a cytokine, it has an additional nuclear role. Therefore, we used biotin proximity labelling to explore the protein interactome of pro-IL-1a with the aim to investogate possible additional roles of this protein. We have suggested in our study that interaction with histone acetyl trasnferases may suggest a possible nuclear function of pro-IL-1a.
