Project description:We announce the draft genome sequence of Mycobacterium austroafricanum DSM 44191(T) (= E9789-SA12441(T)), a non-tuberculosis species responsible for opportunistic infection. The genome described here has a size of 6,772,357 bp with a G+C content of 66.79% and contains 6,419 protein-coding genes and 112 RNA genes.
Project description:We employed a proteogenomics workflow to identify microproteins encoded by small Open Reading Frames (ORFs) in the genome of Mycobacterium smegmatis strain mc²155.
Project description:Related surrogate species are often used to study the molecular basis of pathogenicity of a pathogen on the basis of a shared set of biological features generally attributable to a shared core genome consisting of orthologous genes. An important and understudied aspect, however, is the extent to which regulatory features affecting the expression of such shared genes are present in both species. Here we report on an analysis of whole transcriptome maps for an important member of the TB complex Mycobacterium bovis and a closely related model organism for studying mycobacterial pathogenicity Mycobacterium marinum.
