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RNA-seq of mouse BMDCs treated with compound #634 or vehicle controls

ABSTRACT: RNA-seq of mouse BMDCs treated with compound #634 or vehicle controls

PROVIDER: PRJEB57694 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR10498258_1.fastq.gz	Fastqsanger.gz
	ERR10498258_2.fastq.gz	Fastqsanger.gz
	ERR10498259_1.fastq.gz	Fastqsanger.gz
	ERR10498259_2.fastq.gz	Fastqsanger.gz
	ERR10498260_1.fastq.gz	Fastqsanger.gz

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RNA-seq of mouse BMDCs treated with compound #634 or vehicle controls

Project description:We performed RNA-seq analysis to explore the effects of compound #634 (ethyl 2-(benzo[c][1,2,5]thiadiazole-4-sulfonamido)-4,5-dimethylthiophene-3-carboxylate) on RNA transcription of bone marrow-derived dendritic cells (BMDCs).

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Gene expression profiles of mice BMDCs treated with Nitidine Chloride or vehicle following LPS stimulation

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Expression data from BMDCs treated with BI2536 or vehicle control and stimulated with LPS or poly(I:C)

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Genes altered by miR-634 in three cancer cell lines

Project description:To identify genes affected by miR-634 overexpression, we transfected with 20nmol of miR-634 or miR-negative control (NC) in HeLa, KYSE850, or U2OS cells. After 2 days, RNA was extracted, and then expression analysis was performed using agilent microarray.

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miR-634 restores drug sensitivity in resistant ovarian cancer cells by targeting the Ras-MAPK pathway

Project description:The development of drug resistance is still a major impediment for the successful treatment of cancer, such as advanced stage ovarian cancer, which has a 5-year survival rate of only 30%. The molecular processes that contribute to resistance have been extensively studied, however, not much is known about the role of microRNAs. We compared microRNA expression profiles of three isogenic cisplatin sensitive and resistant cell line pairs. The only microRNA that was consistently downregulated (FDR = 0.000) in all resistant cell lines was miR-634. We investigated the effects of miR-634 modulation in ovarian cancer cell lines and patient derived tumor cells. Overexpression of miR-634 gave rise to a modest G1 phase block and enhanced apoptosis. Furthermore, miR-634 resensitized resistant ovarian cancer cell lines and patient derived tumor cells to cisplatin chemotherapy. Similarly, miR-634 enhanced the response of tumor cells to carboplatin and doxorubicin, but not to paclitaxel. We showed that miR-634 regulates cyclin D1 (CCND1), which is required for the G1-S phase transition, explaining the effects on the cell cycle. In addition, miR-634 repressed expression of GRB2, ERK2, RSK1 and RSK2, components of the Ras-MAPK pathway. Altogether, our findings suggest that miR-634 modulates several cancer relevant targets and therefore miR-634 is an attractive therapeutic candidate to resensitize chemotherapy resistant ovarian tumors.

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Klebsiella variicola CAG:634

Project description:Klebsiella variicola CAG:634 overview

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Genes altered by miR-634 in three cancer cell lines

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