Samples Ukraine patients
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ABSTRACT:
PROVIDER: PRJEB58365 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Whole genome sequencing of 177 clinical isolates from Ukraine 2015
| PRJEB26996 | ENA
Project description:Leather was one of the most important materials of nomadic Scythians, who used it for clothing, shoes, and quivers, amongst other objects. However, we have little information about the animal species utilised for Scythian leather production. In this first systematic study, we used palaeoproteomics methods to analyse the species in 45 samples of leather and two fur objects recovered from 18 burials excavated at 14 different Scythian sites in southern Ukraine, 3 of which were analysed by LC-MS/MS. Our results demonstrate that Scythians primarily used domesticated species such as sheep, goat, cattle, and horse for the production of leather, while the furs were made of wild animals such as fox, squirrel and feline species. The surprise discovery is the presence of two human skin samples, which for the first time provide direct evidence of the Greek historian Herodotus’ claim that Scythians used the skin of their dead enemies to manufacture leather trophy items, such as quiver covers. We argue that leather manufacture is not incompatible with a nomadic lifestyle and that Scythians possessed sophisticated leather production technologies that ensured stable supply of this essential material.
2023-10-27 | PXD043533 | Pride
Project description:Genomic epidemiology and antimicrobial resistance determinants of Neisseria gonorrhoeae isolates from Ukraine, 2013-2018
| PRJEB36606 | ENA
Project description:Interactions between Trypillian farmers and North Pontic forager-pastoralists in Eneolithic central Ukraine
| PRJEB61755 | ENA
Project description:Latvian and Ukrainian Mesolithic and Neolithic data
| PRJEB18067 | ENA
Project description:Objectives: Although in Ukraine the incidence of Lyme borreliosis (LB) has been surging up over the past decades, seroepidemiologic data are not available to date. The objective of this report was to perform preliminary serological survey of hospitalized population for LB. Methods: Sera were collected from 203 patients of a hospital located in Western Ukraine. Most patients showed clinical signs that were compatible with LB such as arthritis (n = 29), neurological signs (n = 35), and erythema migrans (EM)-like lesions (n = 60) or unrelated to LB (n = 79). The specimens were tested by enzyme-linked immunosorbent assay and Western blot for anti-Borrelia antibodies. Results: LB was confirmed in 8.6%, 34.5%, and 50% of the patients, who exhibited neurological signs, arthritis, or EM-like lesions, respectively. Anti-Borrelia antibodies were also detected in 6.3% of the patients with pulmonary tuberculosis. Conclusions: This study provides the first preliminary data on the seroprevalence of LB in Ukraine. Future studies are warranted to investigate more subsets of the Ukrainian population for this emerging tick-borne disease.
| S-EPMC7997712 | biostudies-literature
Project description:Ukraine's volatile syndemics of tuberculosis (TB) and HIV among people who inject drugs (PWIDs) introduces numerous treatment challenges for each condition, including high mortality and development of multi-drug resistant TB (MDR-TB).A prospective, non-randomized 90-day observational study was conducted in six Ukrainian TB treatment sites to assess the effectiveness of integrating methadone maintenance (MMT) with TB treatment using: (1) 90-day TB treatment retention; (2) time to treatment discontinuation; (3) TB medication adherence; and (4) subject disposition, including mortality. Of the 110 participants enrolled, 57 received MMT and 53 did not (non-MMT).All of the primary outcomes were significantly better in MMT versus non-MMT groups, including 90-day TB treatment completion (89.5% versus 73.6%; p=0.031), time to TB treatment discontinuation (p=0.039) and TB medication adherence (97.1% versus 86.2%; p<0.001) after controlling for death. The major reasons for treatment non-completion in the non-MMT group included death (N=3), administrative discharge from the clinic (N=5), loss to follow-up (N=2), and arrest (N=4). Overall, 90-day mortality was high (8.2%). After controlling for covariates differing between the two groups at baseline, the only independent predictor of completing 90 days of TB treatment was receipt of MMT in an integrated treatment setting (AOR=3.05; 95% CI 1.08-8.66).MMT integrated into inpatient TB treatment significantly improves retention in TB treatment and TB medication adherence among PWIDs. These findings call for policy change to increase the number of MMT sites in TB facilities and make MMT a low-threshold treatment option for opioid dependence in Ukraine.
| S-EPMC5553122 | biostudies-other
Project description:BackgroundThe main goal of this collaborative effort is to provide genome-wide data for the previously underrepresented population in Eastern Europe, and to provide cross-validation of the data from genome sequences and genotypes of the same individuals acquired by different technologies. We collected 97 genome-grade DNA samples from consented individuals representing major regions of Ukraine that were consented for public data release. BGISEQ-500 sequence data and genotypes by an Illumina GWAS chip were cross-validated on multiple samples and additionally referenced to 1 sample that has been resequenced by Illumina NovaSeq6000 S4 at high coverage.ResultsThe genome data have been searched for genomic variation represented in this population, and a number of variants have been reported: large structural variants, indels, copy number variations, single-nucletide polymorphisms, and microsatellites. To our knowledge, this study provides the largest to-date survey of genetic variation in Ukraine, creating a public reference resource aiming to provide data for medical research in a large understudied population.ConclusionsOur results indicate that the genetic diversity of the Ukrainian population is uniquely shaped by evolutionary and demographic forces and cannot be ignored in future genetic and biomedical studies. These data will contribute a wealth of new information bringing forth a wealth of novel, endemic and medically related alleles.
| S-EPMC7804371 | biostudies-literature
Project description:We compared the expression profiles of papillary thyroid tumors from the Chernobyl Tissues Bank (CTB) with tumors from French patients with no history of exposure to radiations. Keywords: papillary thyroid cancer vs. patient-matched healthy adjacent thyroid thyroid papillary cancer vs. patient-matched adjacent nontumor thyroid tissues. -14 tumors from France -12 tumors from Ukraine
2007-07-11 | E-GEOD-3950 | biostudies-arrayexpress