Project description:To explore the molecular mechanisms involved in the toxicity in the livers exposed to MC-LR at the environmental level, the hepatic transcriptome was performed. A total of 210 genes were differentially expressed (P<0.05, |fold change|≥2) in response to MC-LR exposure; among them, 143 genes were significantly upregulated, and 67 genes were downregulated. Pathway enrichment analysis identified the top biological functions associated with the genes differentially expressed in response to MC-LR exposure, which were circadian regulation of gene expression, negative regulation of glucocorticoid receptor signaling pathway, the epoxygenase P450 pathway, regulation of insulin secretion, lipid metabolic process, and cell cycle pathway.

2020-03-25 | GSE145459 | GEO

Intestinal microflora

Project description:Intestinal microflora Metagenome

| PRJNA491784 | ENA

MC-LR induced piRNA changes in mouse sperm

Project description:The expressions of piRNA in mouse sperm were altered by MC-LR-exposure or Hsp90aa1 shRNA. MC-LR could induce intergenerational toxicity.

2020-12-31 | GSE129849 | GEO

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