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ScRNA-seq of lung CD140a+ mesenchymal cells from AT3-gcsf tumor-bearing mice

ABSTRACT: scRNA-seq of lung CD140a+ mesenchymal cells from AT3-gcsf tumor-bearing mice

PROVIDER: PRJEB59361 | ENA |

REPOSITORIES: ENA

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scRNA-seq of lung CD140a+ mesenchymal cells from AT3-gcsf tumor-bearing mice

Project description:To characterize lung CD140a+ mesenchymal cells in host neutrophilic inflammation conditions, we isolated lung CD140a+ mesenchymal cells from AT3-gcsf tumor-bearing CD140a-EGFP mice for scRNA-seq.

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scRNA-seq of lung CD140a+ mesenchymal cells from naïve or tumor-bearing CD140aEGFP reporter mice

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scRNA-seq of lung CD140a+ mesenchymal cells (fibroblasts) from CD140a-EGFP reporter mice

Project description:To investigate the heterogeneity of lung CD140a+ mesenchymal cells (fibroblasts) and identify the specific lung fibroblast subset, we purified CD140a+ lung cells using CD140a-EGFP reporter mice for a higher-resolution scRNA-seq.

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scRNA-seq of lung CD140a+ mesenchymal cells from naïve or tumor-bearing CD140aEGFP reporter mice

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RNA-seq of ex vivo cultured lung CD140a+ mesenchymal cells (fibroblasts) upon stimulation by IL-1β

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CD140a+ human oligodendrocyte progenitor cells

Project description:Glial progenitor cells (GPCs) pervade the human brain. These cells express gangliosides recognized by MAb A2B5, and some but not all can generate oligodendrocytes. Since some A2B5+ GPCs express PDGFa receptor (PDGFRa), which is critical to oligodendrocyte development, we asked if PDGFRa-directed sorting might isolate oligodendrocyte-competent progenitors. We used FACS to sort PDGFRa+ cells from the second trimester fetal human forebrain, based on expression of the PDGFRa epitope CD140a. CD140a+ cells could be maintained as mitotic progenitors that could be instructed to either oligodendrocyte or astrocyte phenotype. Transplanted CD140a+ cells robustly myelinated the hypomyelinated shiverer mouse brain. Microarray confirmed that CD140a+ cells differentially expressed PDGFRA, NG2, OLIG1/2, NKX2.2 and SOX2. Some expressed CD9, thereby defining a CD140a+/CD9+ fraction of oligodendrocyte-biased progenitors. CD140a+ cells differentially expressed genes of the PTN-PTPRZ1, wnt, notch and BMP pathways, suggesting the interaction of self-renewal and fate-restricting pathways in these cells, while identifying targets for their mobilization and instruction.

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