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Identification of novel and already known altered micoRNAs lead to a deeper understanding of the development of type 1 diabetes mellitus

ABSTRACT: Identification of novel and already known altered micoRNAs lead to a deeper understanding of the development of type 1 diabetes mellitus

PROVIDER: PRJEB59759 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR10862800.fastq.gz	Fastqsanger.gz
	ERR10862801.fastq.gz	Fastqsanger.gz
	ERR10862802.fastq.gz	Fastqsanger.gz
	ERR10862803.fastq.gz	Fastqsanger.gz
	ERR10862804.fastq.gz	Fastqsanger.gz

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Identification of novel and already known altered micoRNAs lead to a deeper understanding of the development of type 1 diabetes mellitus

Project description:Type 1 diabetes is a chronic autoimmune disease which results in inefficient regulation of glucose homeostasis and can lead to different vascular comorbidities through life. Next generation sequencing analysis was firstly performed to identify miRNAs that were differentially expressed between groups (20 patients vs. 10 controls). The aim of this study is to analyze the expression profile of circulating miRNAs in the plasma of adult patients with well-established type 1 diabetes and with no associated comorbidities, compared to healthy subjects, to identify miRNAs that are specific from diabetes pathology, and to assess pathways and biological processes related to the state of this disease.

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Project description:Identification of novel and already known altered micoRNAs would lead to a deeper understanding of the development of type 1 diabetes mellitus.

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Project description:To evaluate whether serum micoRNAs can be biomarkers for diagnosis of type 1 diabetes mellitus, we analyzed the serum microRNA expression profiles in 6 patients with new-onset type 1 diabetes mellitus and 6 age- and gender-matched healthy controls. A difference was observed in 31 miRNAs between the patients and controls (fold change ≥ 2, P < 0.05)

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