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Transcriptional profiling of murine distal colon from C57BL/6 (WT) and Stat2KO mice during acute DSS colitis.

ABSTRACT: Transcriptional profiling of murine distal colon from C57BL/6 (WT) and Stat2KO mice during acute DSS colitis.

PROVIDER: PRJEB60040 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR10905147_1.fastq.gz	Fastqsanger.gz
	ERR10905147_2.fastq.gz	Fastqsanger.gz
	ERR10905148_1.fastq.gz	Fastqsanger.gz
	ERR10905148_2.fastq.gz	Fastqsanger.gz
	ERR10905149_1.fastq.gz	Fastqsanger.gz

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Project description:In humans with UC, low-grade dysplasia also develops predominantly in the distal colon, progresses more rapidly to neoplasia than proximal colon low-grade dysplasia and associates with worse patient prognosis. In a mouse model of colitis-associated carcinogenesis induced by administration of the mutagen AOM and the luminal toxin DSS, tumors also develop exclusively in the distal part of the large intestine. We monitored global changes in the transcriptome of mouse proximal and distal colon during exposure to AOM/DSS with the aim to define biological pathways and processes that characterize regional responses of the large intestine to colitis-associated carcinogenesis.

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Transcriptional profiling of murine distal colon from C57BL/6 (WT) and Stat2KO mice during acute DSS colitis.

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Transcriptional profiling of murine distal colon from C57BL/6 (WT), Il20KO, Il20raKO and Il20rbKO mice during acute DSS colitis

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