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Transcriptome analysis of Cryptococcus neoformans strain H99 in response to exposure to amphotericin B

ABSTRACT: Transcriptome analysis of Cryptococcus neoformans strain H99 in response to exposure to amphotericin B

PROVIDER: PRJEB60273 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR10936451_1.fastq.gz	Fastqsanger.gz
	ERR10936451_2.fastq.gz	Fastqsanger.gz
	ERR10936452_1.fastq.gz	Fastqsanger.gz
	ERR10936452_2.fastq.gz	Fastqsanger.gz
	ERR10936453_1.fastq.gz	Fastqsanger.gz

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Transcriptome analysis of Cryptococcus neoformans strain H99 in response to exposure to amphotericin B

Project description:Log phase of Cryptococcus neoformans strain H99 was exposed to amphotericin B (1.5μg/ml) or vehicle (control) for 3h. Transcriptome of drug treated cells were compared to no treatment cells.

2023-08-16 | E-MTAB-12683 | biostudies-arrayexpress

Transcriptomics analysis of amphotericin B and lactoferrin drug synergy in Cryptococcus neoformans H99

Project description:Invasive fungal infections (IFIs) are difficult to treat. Few effective antifungal drugs are available and many have problems with toxicity, efficacy and drug-resistance. To overcome these challenges, existing therapies may be enhanced using more than one agent acting in synergy. Previously, we have found amphotericin B (AMB) and the iron chelator, lactoferrin (LF), were synergistic against Cryptococcus neoformans and Saccharomyces cerevisiae. This study investigates the mechanism of AMB+LF synergy using RNA-seq in Cryptococcus neoformans H99.

2019-09-08 | GSE130375 | GEO

DNA-seq of Cryptococcus neoformans H99 derived amphotericin B adaptors

Project description:Approximately 1 million cells of Cryptococcus neoformans lab strain H99 were spread on YPD plate supplmemented with 3ug/ml amphotericin B. Randomly 30 adaptors (TJ1832 - TJ1861) were chosen. The parent and all the 30 adaptors were sequenced.

2023-05-11 | E-MTAB-12493 | biostudies-arrayexpress

RNA-seq of some amphotericin B adaptors in Cryptococcus neoformans

Project description:Cryptococcus neoformans strain H99 was exposed to 3μg/ml amphotericin B. Among the amphotericin B-tolerant adaptors, transcriptomes of four adaptors (TJ1844, TJ1849, TJ1852, TH1854) were analyzed and compared to wild type strain H99.

2023-08-10 | E-MTAB-12679 | biostudies-arrayexpress

Ribosome profiling of Cryptococcus neoformans H99

Project description:We measured protein translation (by ribosome profiling) and RNA levels (by polyA-enriched RNA-seq) in Cryptococcus neoformans strain H99 and Cryptococcus neoformans strain JEC21. This is the first transcriptome-wide map of translation in this species complex.

2019-06-22 | GSE133125 | GEO

DNA-seq of Cryptococcus neoformans H99 derived amphotericin B adaptors

Project description:DNA-seq of Cryptococcus neoformans H99 derived amphotericin B adaptors

| PRJEB58835 | ENA

Overexpression of the transcription factor GAT201 in Cryptococcus neoformans var. grubii (serotype A, H99)

Project description:Comparison of transcriptional profiles of WT Cryptococcus neoformans (H99) and strain CM126 (pRPL2b-GAT201) which overexpresses the transcription factor GAT201 using a ribosomal protein promoter Keywords: Genetic modification

2008-03-07 | GSE10750 | GEO

Cryptococcus neoformans strain TJ1854 derived amphotericin B adaptors

Project description:In this study, H99 is a wild type Cryptococcus neoformans strain. TJ1854 is a chromosome 4 disomy strain derived from H99. Approximately 1 million cells of TJ1854 were spread on YPD plate supplemented with 6ug/ml amphtericin B. Randomlyh 27 adaptors (TJ2487-TJ2513) were chosen. These adaptors were sequenced.

2023-03-15 | E-MTAB-12480 | biostudies-arrayexpress

RNA sequencing of Cryptococcus neoformans H99 treated with eltrombopag

Project description:The gene expression of C. neoformans H99 treated with eltrombopag

2018-06-12 | GSE115570 | GEO

Cryptococcus neoformans H99-vivo

Project description:Cryptococcus neoformans H99-vivo Transcriptome or Gene expression

| PRJNA191504 | ENA