Project description:The yeast Cyberlindnera fabianii is used in wastewater treatment, fermentation of alcoholic beverages, and has caused blood infections. To assist in the accurate identification of this species, and to determine the genetic basis for properties involved in fermentation and water treatment, we sequenced and annotated the genome of C. fabianii (YJS4271).
Project description:This is genome-scale metabolic model of Cyberlindnera americana as the representative yeast species for the clade Phaffomycetaceae. This model was generated through homology search using a fungal pan-GEM largely based on Yeast8 for Saccharomyces cerevisiae, in addition to manual curation. This model has been produced by the Yeast-Species-GEMs project from Sysbio (www.sysbio.se). This is model version 1.0.0 accompanying the publication (DOI: 10.15252/msb.202110427), currently hosted on BioModels Database and identified by MODEL2109130008. Further curations of this model will be tracked in the GitHub repository: https://github.com/SysBioChalmers/Yeast-Species-GEMs Models for species of the same clade includes: Cyberlindnera fabianii; Cyberlindnera jadinii; Wickerhamomyces anomalus; Wickerhamomyces ciferrii; Starmera quercuum; Candida stellimalicola; Candida freyschussii; Cyberlindnera mrakii; Cyberlindnera misumaiensis; Candida montana; Barnettozyma californica; Barnettozyma hawaiiensis; Barnettozyma populi; Barnettozyma pratensis; Barnettozyma salicaria; Candida ponderosae; Wickerhamomyces hampshirensis; Wickerhamomyces bovis; Wickerhamomyces alni; Wickerhamomyces sp.; Cyberlindnera petersonii; Wickerhamomyces canadensis; Starmera amethionina; Phaffomyces opuntiae; Phaffomyces antillensis; Phaffomyces thermotolerans; Candida orba; Cyberlindnera saturnus; Cyberlindnera suaveolens; Cyberlindnera xylosilytica; Candida mycetangii; Candida vartiovaarae; Cyberlindnera maclurae; Cyberlindnera americana. These models are available in the zip file. To cite BioModels, please use: V Chelliah et al; BioModels: ten-year anniversary. Nucleic Acids Res 2015; 43 (D1): D542-D548. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to MIT License for more information.
Project description:Invasive fungal infections caused by Cyberlindnera fabianii have recently increased. However, biochemical kits such as API 20 C AUX and Vitek-2C have misidentified this species as other Candida spp. such as C. pelliculosa or C. utilis due to no information of Cy. fabianii in yeast database. During our 2016-2017 surveys, eleven isolates of Cy. fabianii were obtained in International St. Mary's Hospital in Korea. Here, we describe its morphological and molecular characteristics and tested its antifungal susceptibility against nine antifungal agents. The sequences of the ITS region and the D1/D2 region of LSU revealed 100% identity with the sequences of Cy. fabianii. In comparison with the results from MALDI-TOF mass spectrometry, we found that Cy. fabianii can be distinguished from other species. In antifungal susceptibility test, voriconazole and echinocandins exhibited good antifungal activities against the majority of Cy. fabianii isolates despite the absence of standard criteria.
