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Store Universal Declaration of Human Rights on DNA molecule

ABSTRACT: Store Universal Declaration of Human Rights on DNA molecule

PROVIDER: PRJEB61441 | ENA |

REPOSITORIES: ENA

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In vitro construct of long artificial DNA sequences (no sequence error)

Project description:Store Universal Declaration of Human Rights on DNA molecule

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Universal Endometrial Cancer DNA Sequencing for Detection of Lynch Syndrome and Personalized Care

Project description:This clinical trial studies universal screening for deoxyribonucleic acid (DNA) mismatch repair deficiency in patients with endometrial cancer, mutations in the genes responsible for Lynch syndrome (inherited forms of endometrial cancers) and other DNA changes that could help guide treatment strategies. Universal tumor DNA sequencing may help doctors better understand how to personalize care, increase length of life, and increase quality of life in patients with endometrial cancer and their relatives.

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Selective modulation of gene expression in activated normal human peripheral blood mononuclear cells by store-operated calcium entry blocker BTP2

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2023-08-07 | GSE226570 | GEO

Store Independent Ca2+ Entry Regulates the DNA Damage Response Pathway in Breast Cancer Cells

Project description:The mainstay of treatment for hormone responsive breast tumors is chemotherapy, followed by targeted endocrine therapy. The vast majority (80%) of estrogen receptor positive tumors also express wild type p53 protein that is the main determinant of the DNA damage response. Tumors that are ER+ and p53WT respond poorly to chemotherapy, although the underlying mechanisms are not completely understood. We describe a novel link between store independent Ca2+ entry (SICE) and resistance to DNA damaging drugs, mediated by the secretory pathway Ca2+-ATPase, SPCA2. In luminal ER+/PR+ breast cancer subtypes, SPCA2 levels are high and correlate with poor survival prognosis. Independent of ion pump activity, SPCA2 elevates baseline Ca2+ levels through SICE and drives cell proliferation. Attenuation of SPCA2 led to increased mitochondrial ROS production, DNA damage and activation of the ATM/ATR-p53 axis leading to G0/G1 phase cell cycle arrest and apoptosis. Resistance to DNA damaging agents including doxorubicin, carboplatin, and ionizing radiation could be reversed by downregulation of SPCA2 expression using curcumin. In conclusion, elevated SPCA2 drives pro-survival and chemotherapy resistance in ER+ p53WT breast tumors by suppressing the DNA damage response. Attenuation of SPCA2 expression by curcumin may have therapeutic potential in treating receptor positive breast cancer. The goal of this study is to investigate store Independent Ca2+ entry regulation of the DNA Damage Response pathway in breast cancer cells

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Mammalian oocytes store proteins in cytoplasmic lattices

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Store Independent Ca2+ Entry Regulates the DNA Damage Response Pathway in Breast Cancer Cells

Project description:Store Independent Ca2+ Entry Regulates the DNA Damage Response Pathway in Breast Cancer Cells

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H9 hES cells vs. universal RNAs

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Mammalian oocytes store proteins in cytoplasmic lattices

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Stratagene Universal Human RNA Hybridized to Affymetrix U133 Plus 2.0 and U133 A Chips

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Project description:Development of HLA engineered universal vascular grafts from human iPSCs

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