Project description:Salmonella species infect many vertebrate species, and pigs colonized with Salmonella enterica serovar Typhimurium (ST) are usually asymptomatic, making detection of these Salmonella-carrier pigs difficult. The variable fecal shedding of this gram-negative bacteria in such pigs is an important cause of foodborne illness and zoonotic disease. To investigate gene pathways and biomarkers associated with the variance in Salmonella shedding following experimental inoculation, we have initiated the first analysis of the whole blood transcriptional response induced by Salmonella. A population of pigs (n=40) was inoculated with ST and the peripheral blood and feces were collected between 2 and 20 days post-inoculation. Two groups of pigs with either low shedding (LS) or persistent shedding (PS) phenotypes were identified. The global transcriptional changes in response to ST inoculation were identified by Affymetrix Genechip?analysis of peripheral blood RNA at day 0 and day 2 post-inoculation.

2011-05-28 | GSE27000 | GEO

Expression analysis of Salmonella typhimurium LT2 TA100 upon exposure to C60

2012-09-01 | GSE35750 | GEO

Microbiomes of lymphatic organs and slaughter contamination

Project description:Microbiomes of lymphatic organs and slaughter contamination

| PRJEB9066 | ENA

Methylome of Salmonella enterica subsp. Enterica serovar Javiana str. CFSAN001992 by PacBio SMRT Sequencing

Project description:Single-molecule read technologies allow for detection of epigenomic base modifications during routine sequencing by analysis of kinetic data during the reaction, including the duration between base incorporations at the elongation site (the "inter-pulse duration.") Methylome data associated with a closed de novo bacterial genome of Salmonella enterica subsp. enterica serovar Javiana str. CFSAN001992 was produced and submitted to the Gene Expression Omnibus. Single-sample sequencing and base modification detection of cultured isolate of a foodborne pathogen.

2013-03-15 | E-GEOD-45178 | biostudies-arrayexpress

Expression data from broiler chickens in response to the combined stressors of catching, transport and slaughter

Project description:The process of commercial catching, transport and slaughter (CTS) is known to be an acute stressful event in broiler chickens. Corticosteroid concentrations increase, impacting measures of IGF-1, growth hormone and metabolites of the immune system from blood plasma samples. We used ARK-Genomics chicken 20K oligo array, a two channel DNA microarray, to investigate the significantly differentially expressed genes in the livers of chickens during CTS.

2010-03-19 | GSE20953 | GEO

Peripheral blood transcriptome responses to Salmonella Typhimurium in pigs differing in Salmonella shedding phenotypes

2011-05-28 | E-GEOD-27000 | biostudies-arrayexpress

Expression analysis of Salmonella typhimurium LT2 TA100 upon exposure to C60

Project description:Investigation of gene expression level changes in Salmonella typhimurium LT2 TA100 upon exposure to C60, compared to unexposed controls. The mutations engineered into this strain make it susceptile to mutagenic compounds. The Salmonella typhimurium TA100 strain used in this study is further described in Pedersen P, Thomsen E, Stern RM. 1983. Detection by Replica Plating of False Revertant Colonies Induced in the Salmonella Mammalian Microsome Assay by Hexavalent Chromium. Environmental health perspectives 51: 227-230. A 4 x 72K array study using total RNA recovered from triplicate cultures of Salmonella typhimurium LT2 TA100 exposed to C60 and triplicate cultures of controls that were not exposed to C60. Each 72K array measures the expression level of 4,504 genes from Salmonella typhimurium LT2 with seven 45 to 60-mer probe pairs per gene.

2012-09-01 | E-GEOD-35750 | biostudies-arrayexpress

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