Project description:Interventions: IHC of MMR proteins, genetic or epigenetic analyses of MMR genes
Primary outcome(s): Screening of HNPCC related tumors by IHC for loss of MMR protein expression and observation of the clinical features assciated with MMR deficiency.
Study Design: Single arm Non-randomized
Project description:This work highlights the versatility of combining genetic screens with molecular profiling of cancer cells for high-throughput genetic interaction discovery that will not only offer critical insight into basic regulatory mechanisms of cancer epigenome progression, but also lead to new therapeutic targets for genetically defined and epigenetically perturbed cancers.
Project description:The purpose of this study is to assess the feasibility of selecting personalized therapies for colon cancer patients who have failed standard treatments, using a new methodology based on the determination of a profile of chemosensitivity by comprehensive genetic expression analysis from tumor samples.