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MRNA-Seq of placentas bearing the OgtY851A mutation

ABSTRACT: mRNA-Seq of placentas bearing the OgtY851A mutation

PROVIDER: PRJEB65055 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR11830100_1.fastq.gz	Fastqsanger.gz
	ERR11830100_2.fastq.gz	Fastqsanger.gz
	ERR11830101_1.fastq.gz	Fastqsanger.gz
	ERR11830101_2.fastq.gz	Fastqsanger.gz
	ERR11830102_1.fastq.gz	Fastqsanger.gz

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mRNA-Seq of placentas bearing the OgtY851A mutation

Project description:Heterozygous OgtY851A/WT females were bred with hemizygous OgtY851A/Y males, placentas were dissected at E12.5 and single placenta's halves were processed for mRNA-Seq. Sex and genotypes of the embryos were determined by PCR genotyping of the DNA extracted from the embryonic heads.

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Project description:Here we use a proteomic approach to study the role of the placenta in ZIKV-induced microcephaly and the mechanisms of ZIKV to cross the placental barrier. Samples were separated into three groups: an uninfected control group (ZIKV-CZS-), a group of placentas infected by ZIKV with normal neonates (ZIKV+CZS-), and a group of placentas infected by ZIKV that developed microcephaly in newborns (ZIKV+CZS+). Zika virus causes DNA damage and impairs gene expression and mRNA translation during infection of the placenta. Processes related to viral transcytosis, like endocytosis, autophagy and disruption of actin filament were also observed in CZS-infected placentas, which could lead to a higher virus infiltration. Unncontrolled maternal immune response as well as greater expression of cellular adhesion proteins in the decidua could lead to a disruption of tolerance during pregnancy and induction of neurological malformation of the neonates

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Next Generation Sequencing Facilitates Quantitative Analysis of mRNA expression prolifes in placentas from wild Type,early-onset and later-onset PE mouse models

Project description:Purpose: Next-generation sequencing (NGS) has revolutionized systems-based analysis of cellular pathways. The goals of this study are to compare transcriptome profiling (RNA-seq) of E17.5 placentas from control, early-onset (EO) and later-onset (LO) preeclampsia (PE) mice. Methods: E17.5 placental mRNA profiles of offspring from control, EO and LO PE mice were generated by deep sequencing, using Illumina GAIIx. The sequence reads that passed quality filters were analyzed at the transcript isoform level with two methods: Burrows–Wheeler Aligner (BWA) followed by ANOVA (ANOVA) and TopHat followed by Cufflinks. Results: Using an optimized data analysis workflow, we mapped about 30 million sequence reads per sample to the mouse genome (build mm9) and identified 16,014 transcripts in the E17.5 placentas from control EO and LO PE mice with BWA workflow and 34,115 transcripts with TopHat workflow. R Conclusions: Our study represents the first detailed analysis of E17.5 placentas transcriptomes, with biologic replicates, generated by mRNA-seq technology. The optimized data analysis workflows reported here should provide a framework for comparative investigations of expression profiles. Our results show that NGS offers a comprehensive and more accurate quantitative and qualitative evaluation of mRNA content within tissue. We conclude that mRNA-seq based transcriptome characterization would expedite genetic network analyses and permit the dissection of complex biologic functions.

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